Bcl-2 and Noxa are potential prognostic indicators for patients with gastroenteropancreatic neuroendocrine neoplasms
Bcl-2 and Noxa are potential prognostic indicators for patients with gastroenteropancreatic neuroendocrine neoplasms
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DOI：
10.21203/rs.3.rs-1346706/v1
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Jie Chen
中科院分区：
文献类型：
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作者：
Guo Yu;Zhang Lin;Zhang Ning;Luo Qiuyun;Liu Man;Yang Dajun;Jie Chen
Purpose Bcl-2 family of proteins are of great significance in the pathogenesis and development of tumor. In this study, the relationship between the expression of Bcl-2 family proteins and clinicopathological features and prognosis of NENs were further investigated. Methods 105 Patients diagnosed with gastroenteropancreatic NENs (GEP-NENs) with the paraffin specimen of the tumor available were retrospectively included, immunohistochemistry (IHC) was performed to detect the expression of Bcl-2 family proteins in paraffin-embedded samples. Student’s t test and Chi-square test were applied to compare the difference of quantitative and categorical variables, respectively. Prognosis analysis was conducted according to Kaplan⁃Meier method. Univariate COX and multivariate COX regression analysis were used to screen out the independent prognostic factors. Results The IHC score of Bcl-2 was significant higher in neuroendocrine carcinomas (NECs) patients (65.6% vs. 38.4%, P = 0.010), while higher IHC score of Noxa was more common in neuroendocrine tumors (NETs) patients (49.3% vs. 25.0%, P = 0.020). Survival analysis suggested that patients with higher Bcl-2 expression and lower Noxa expression had worse survival rate (42.9% vs. 73.2%, P < 0.001; 42.6% vs. 81.8%, P < 0.001). Multivariate cox analysis indicated that high Bcl-2 expression was an independent factor associated with poor DFS (hazard ratio [HR]: 2.661; 95% confidence interval [CI]: 1.385–5.110) and poor OS (HR: 3.205; 95% CI: 1.587–6.473; P = 0.001), while higher Noxa expression was associated with improved DFS (HR:0.324; 95% CI: 0.147–0.713) and better OS (HR: 0.293; 95% CI: 0.126–0.684). Conclusion Higher expression of Bcl-2, and lower expression of Noxa were associated with unfavorable prognosis of GEP-NEN patients.
