Long-term stability of sensitivity to intracortical microstimulation of somatosensory cortex
Long-term stability of sensitivity to intracortical microstimulation of somatosensory cortex
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DOI：
10.1088/1741-2560/12/5/056010
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发表时间：
2015-10-01
影响因子：
4
通讯作者：
Bensmaia, Sliman J.
中科院分区：
文献类型：
--
作者：
Callier, Thierri;Schluter, Erik W.;Bensmaia, Sliman J.
目标。对物体的灵巧操作在很大程度上依赖于肢体的体感信号。拟人化机械臂的发展和从神经元信号中解码预期动作的算法的发展，刺激了恢复躯体感觉以用于上肢神经假体的需求。如果没有触摸和本体感觉，患者很难将假肢控制到需要进行侵入性手术的水平。通过长期植入电极阵列的皮层内微刺激(ICMS)具有提供丰富和直观的感觉反馈的潜力。然而，这种恢复感觉的方法要求被唤起的感觉在一段时间内保持稳定。接近。为了研究ICMS诱发感觉的稳定性，我们测量了非人类灵长类动物在跨越数年的实验期间检测ICMS的能力。主要结果。我们发现，动物的表现随着时间的推移保持高度稳定，即使它们接受了经历了广泛刺激的电极的测试。意义重大。鉴于它所唤起的感觉的稳定性，ICMS因此可能是一种可行的感觉恢复方法。
Objective. The dexterous manipulation of objects depends heavily on somatosensory signals from the limb. The development of anthropomorphic robotic arms and of algorithms to decode intended movements from neuronal signals has stimulated the need to restore somatosensation for use in upper-limb neuroprostheses. Without touch and proprioception, patients have difficulty controlling prosthetic limbs to a level that justifies the required invasive surgery. Intracortical microstimulation (ICMS) through chronically implanted electrode arrays has the potential to provide rich and intuitive sensory feedback. This approach to sensory restoration requires, however, that the evoked sensations remain stable over time. Approach. To investigate the stability of ICMS-evoked sensations, we measured the ability of non-human primates to detect ICMS over experimental sessions that spanned years. Main results. We found that the performance of the animals remained highly stable over time, even when they were tested with electrodes that had experienced extensive stimulation. Significance. Given the stability of the sensations that it evokes, ICMS may thus be a viable approach for sensory restoration.