INHIBITORY ROLE OF THE ENDOTHELIUM IN THE RESPONSE OF ISOLATED CORONARY-ARTERIES TO PLATELETS
INHIBITORY ROLE OF THE ENDOTHELIUM IN THE RESPONSE OF ISOLATED CORONARY-ARTERIES TO PLATELETS
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DOI：
10.1126/science.6574604
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
VANHOUTTE, PM
中科院分区：
文献类型：
--
作者：
COHEN, RA;SHEPHERD, JT;VANHOUTTE, PM
自体血小板聚集引起犬离体左回旋动脉环收缩。收缩增强后，去除内皮细胞和衰减的肾上腺素能受体拮抗剂。在由前列腺素F2 α引起的收缩期间，聚集的血小板引起张力的短暂增加，随后是具有内皮的动脉的深度松弛，但仅引起没有内皮的动脉的进一步收缩。这些观察结果表明，血管内皮在对抗由聚集的血小板释放的5-羟色胺和其他物质引起的冠状血管收缩中的重要性。
Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2.alpha., aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets.