A temporal analysis of the central neural processing of itch
A temporal analysis of the central neural processing of itch
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DOI：
10.1111/j.1365-2133.2012.10849.x
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发表时间：
2012-05-01
影响因子：
10.3
通讯作者：
Griffiths, C. E. M.
中科院分区：
文献类型：
--
作者：
Kleyn, C. E.;McKie, S.;Griffiths, C. E. M.
背景 瘙痒或瘙痒是过敏性和炎症性皮肤病最常见的症状。尽管众所周知，瘙痒会引起大脑中神经网络的激活，但该网络的时间动态以及病理生理学和神经生物学尚不清楚。 目的 该研究旨在阐明 (i) 早期研究中发现的瘙痒反应的时间动态，以及 (ii) 对瘙痒的中枢反应和主观反应之间的关系。 方法 使用新颖的时间序列分析，我们进行了双盲、安慰剂对照、随机、受试者内功能磁共振成像(fMRI) 通过跟踪单次皮肤刺痛后 8 分钟的时间，对健康志愿者 (n = 16) 组胺引起的瘙痒的大脑处理进行研究。结果与生理盐水相比，组胺引起的瘙痒导致中/颞上回和右额下回/岛叶出现显着的曲线下面积血氧水平依赖性 (BOLD) 信号变化。与生理盐水相比，我们在（i）前扣带皮层（ACC）/内侧额叶回，（ii）膝下 ACC/腹侧纹状体，（iii）双侧颞极/海马旁回和（iv）小脑内的几个区域观察到瘙痒引起的负 BOLD 信号变化。我们注意到运动皮层左侧中央前回部分的趋势显着性。其中几个区域的 BOLD 信号变化与瘙痒强度的感知相关。结论与其他功能磁共振成像研究相比，我们观察到多灶性负信号。从长远来看，更好地了解瘙痒反应期间激活和失活的大脑区域可能有助于制定更有效的管理策略。
Background Pruritus, or itch, is the most prevalent symptom of allergic and inflammatory skin disease. Although it is known that itch induces activation of a neural network in the brain, the temporal dynamics of the network as well as the pathophysiology and neurobiology are not well understood.Objectives The study aimed to elucidate (i) the temporal dynamics of the itch response identified in earlier studies and (ii) the relationship between central and subjective responses to itch.Methods Using a novel time-series analysis, we performed a double-blind, placebo-controlled, randomized, within-subject functional magnetic resonance imaging (fMRI) study of the cerebral processing of histamine-induced itch in healthy volunteers (n = 16) by tracking the 8-min period following a single skin prick.Results Histamine-induced itch compared with saline resulted in significant area under the curve blood oxygen level dependent (BOLD) signal changes in the middle/superior temporal gyrus and right inferior frontal gyrus/insula. We observed negative itch-induced BOLD signal changes compared with saline in (i) the pregenual anterior cingulate cortex (ACC)/medial frontal gyrus, (ii) subgenual ACC/ventral striatum, (iii) bilateral temporal pole/parahippocampal gyrus and (iv) several regions within the cerebellum. We noted a trend significance in the left precentral gyrus part of the motor cortex. The BOLD signal change in several of these regions correlated with perception of itch intensity.Conclusions In contrast to other fMRI studies we observed a multifocal negative signal. An improved understanding of both activated and deactivated brain regions during the itch response may in the long term facilitate development of more effective management strategies.