Measurement of spinal cord atrophy in multiple sclerosis
Measurement of spinal cord atrophy in multiple sclerosis
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DOI：
10.1111/j.1552-6569.2004.tb00275.x
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发表时间：
2004-07-01
影响因子：
2.4
通讯作者：
Constantinescu, CS
中科院分区：
文献类型：
--
作者：
Lin, X;Tench, CR;Constantinescu, CS
在多发性硬化症(MS)中，脊髓是一个常见的受累区域，其功能障碍可能是导致大部分运动障碍的原因。据报道，颈髓萎缩发生在早期，并可在出现临床孤立综合征的患者中检测到。这一发现对MS患者的早期治疗具有重要意义，因为萎缩被认为反映了破坏性的、不可逆转的病理和亚临床损害。最近对疾病改良剂的临床试验包括脊髓成像，特别是测量萎缩，作为治疗效果的次要或探索性测量。本文综述了引起脊髓萎缩的基本病理和测量脊髓萎缩的方法。脊髓萎缩，其他磁共振成像参数，和临床残疾之间的关系也被讨论。
In multiple sclerosis (MS), the spinal cord is a common area of involvement, and its dysfunction is likely to be responsible for much of motor disability. It has been reported that atrophy in the cervical spinal cord occurs early and is detectable in patients presenting with a clinically isolated syndrome. This finding has important implications for the early treatment of patients with MS because atrophy is thought to reflect destructive, irreversible pathology and subclinical impairment. Recent clinical trials of disease-modifying agents have included spinal cord imaging and, in particular, the measurement of atrophy as a secondary or exploratory measure of treatment efficacy. This review summarizes the underlying pathology responsible for spinal cord atrophy and the methods available to measure it. The relationships between spinal cord atrophy, other magnetic resonance imaging parameters, and clinical disability are also discussed.