Multimodal Immunosuppressant Therapy in Steroid-Refractory Common Variable Immunodeficiency Sprue: A Case Report Complicating Cytomegalovirus Infection
Multimodal Immunosuppressant Therapy in Steroid-Refractory Common Variable Immunodeficiency Sprue: A Case Report Complicating Cytomegalovirus Infection
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类固醇难治性常见变异型免疫缺陷口炎性腹泻的多模式免疫抑制剂治疗：并发巨细胞病毒感染的病例报告
DOI：
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发表时间：
2006
影响因子：
1.2
通讯作者：
R. Panaccione
中科院分区：
文献类型：
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作者：
S. Medlicott;S. Coderre;G. Horne;R. Panaccione
免疫缺陷患者可发生吸收不良，临床和组织学上类似乳糜泻。这些个体偶尔也可能需要免疫抑制治疗自身免疫性疾病。我们发现了一名普通变异型免疫缺陷（CVID）相关口炎性腹泻患者，在接受皮质类固醇和辅助免疫调节治疗后并发十二指肠巨细胞病毒（CMV）感染。更昔洛韦和免疫抑制剂方案的修改改善了临床症状和绒毛萎缩。据我们所知，这是继发于免疫调节治疗激素难治性CVID-口炎性腹泻的十二指肠CMV感染的原始文献。
Immunodeficient patients can develop malabsorption, mimicking celiac disease clinically and histologically. Such individuals may also occasionally require immunosup pressive therapy for autoimmune disorders. We have identified a patient with common variable immunodeficiency (CVID)-associated sprue complicated by duodenal cytomegalovirus (CMV) infection following corticosteroid and ancillary immunomodulatory therapy. Ganciclovir and a modification of the immunosuppressant regimen improved both clinical symptoms and villous atrophy. To our knowledge, this is original documentation of duodenal CMV infection secondary to immunomodulatory therapy for steroid-refractory CVID-sprue.
影响因子：
158.5
作者：
MERIGAN, TC;RENLUND, DG;STINSON, EB
通讯作者：
STINSON, EB