Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations.
Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations.
复制标题
使用光谱白光光学相干断层扫描检测仓鼠颊囊中的癌前病变，通过光谱振荡评估核形态。
DOI：
10.1117/1.3269680
复制
发表时间：
2009
影响因子：
3.5
通讯作者：
Wax,Adam
中科院分区：
文献类型：
--
作者：
Graf,RobertN;Robles,FranciscoE;Chen,Xiaoxin;Wax,Adam
We have developed a novel dual-window approach for spectroscopic optical coherence tomography (OCT) measurements and applied it to probe nuclear morphology in tissue samples drawn from the hamster cheek pouch carcinogenesis model. The dual-window approach enables high spectral and depth resolution simultaneously, allowing detection of spectral oscillations, which we isolate to determine the structure of cell nuclei in the basal layer of the epithelium. The measurements were executed with our parallel frequency domain OCT system, which uses light from a thermal source, providing high bandwidth and access to the visible portion of the spectrum. The structural measurements show a highly statistically significant difference between untreated (normal) and treated (hyperplastic/dysplastic) tissues, indicating the potential utility of this approach as a diagnostic method.
