Diabetic nephropathy--emerging epigenetic mechanisms.
Diabetic nephropathy--emerging epigenetic mechanisms.
复制标题
DOI：
10.1038/nrneph.2014.116
复制
发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Natarajan R
中科院分区：
文献类型：
--
作者：
Kato M;Natarajan R
糖尿病肾病（DN）是1型和2型糖尿病常见的严重微血管并发症，是肾功能衰竭的主要原因。它还可能导致加速心血管疾病和大血管并发症。目前可用的治疗方法在治疗DN中并不完全有效，这表明进一步了解DN发病机制的分子机制对于改善这种疾病的管理是必要的。虽然已经确定了关键的信号转导和基因调控机制，特别是那些与高血压、转化生长因子-β1和血管紧张素II的作用相关的机制，但功能基因组学、高通量测序技术、表观遗传学和系统生物学方法的进展极大地扩展了我们的知识基础，并发现了新的参与DN的分子机制和因素。这些机制包括DNA甲基化、染色质组蛋白修饰、新型转录物和功能性非编码RNA，如microRNA和长非编码RNA。在这篇综述中，我们将讨论这些新出现的机制的意义，它们如何介导生长因子的作用，以增加细胞外基质和炎症基因的表达与DN，其潜在的有用性作为诊断生物标志物或新的治疗靶点DN。
Diabetic nephropathy (DN), a severe microvascular complication frequently associated with both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. It can also lead to accelerated cardiovascular disease and macrovascular complications. Currently available therapies have not been fully efficacious in the treatment of DN, suggesting that further understanding of the molecular mechanisms underlying the pathogenesis of DN is necessary for the improved management of this disease. Although key signal transduction and gene regulation mechanisms have been identified, especially those related to the effects of hyperglycaemia, transforming growth factor-β1 and angiotensin II, progress in functional genomics, high-throughput sequencing technology, epigenetics and systems biology approaches have greatly expanded our knowledge base and uncovered new molecular mechanisms and factors involved in DN. These mechanisms include DNA methylation, chromatin histone modifications, novel transcripts and functional noncoding RNAs such as microRNAs and long noncoding RNAs. In this Review, we will discuss the significance of these emerging mechanisms, how they mediate the actions of growth factors to augment the expression of extracellular matrix and inflammatory genes associated with DN, and their potential usefulness as diagnostic biomarkers or novel therapeutic targets for DN.
登录
查看更多内容
影响因子：
3.7
作者：
Barutta F;Tricarico M;Corbelli A;Annaratone L;Pinach S;Grimaldi S;Bruno G;Cimino D;Taverna D;Deregibus MC;Rastaldi MP;Perin PC;Gruden G
通讯作者：
Gruden G
影响因子：
12.4
作者：
Chen, Hai-Yong;Zhong, Xiang;Lan, Hui Y.
通讯作者：
Lan, Hui Y.
DOI：
10.1152/ajprenal.2001.280.3.f495
发表时间：
2001-03-01
影响因子：
4.2
作者：
Chin, BY;Mohsenin, A;Choi, ME
通讯作者：
Choi, ME
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
7.4
作者：
Babelova, Andrea;Avaniadi, Despina;Brandes, Ralf P.
通讯作者：
Brandes, Ralf P.