Taurine Improves Lipid Metabolism and Skeletal Muscle Sensitivity to Insulin in Rats Fed with High Sugar and High Fat Diet.
Taurine Improves Lipid Metabolism and Skeletal Muscle Sensitivity to Insulin in Rats Fed with High Sugar and High Fat Diet.
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DOI：
10.1007/978-981-13-8023-5_12
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发表时间：
2019
影响因子：
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通讯作者：
Dong-dong Zhao;Qiufeng Lv;Jiancheng Yang;Gaofeng Wu;Mei Liu;Qunhui Yang;Jie Han;Ying Feng;Shumei Lin;Jianmin Hu
中科院分区：
文献类型：
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作者：
Dong-dong Zhao;Qiufeng Lv;Jiancheng Yang;Gaofeng Wu;Mei Liu;Qunhui Yang;Jie Han;Ying Feng;Shumei Lin;Jianmin Hu
代谢综合征是一种由高营养状况和缺乏运动引起的与生活方式相关的疾病。肥胖引起的胰岛素抵抗作为代谢综合征的潜在机制引起了人们的关注。胰岛素抵抗是指胰岛素靶组织的胰岛素敏感性降低。在这种情况下，为了维持正常的血糖水平，代偿性地释放大量胰岛素，导致高胰岛素血症的发生。牛磺酸广泛分布于动物组织中。牛磺酸虽然不参与蛋白质合成，但对维持机体生理功能具有重要作用。本实验采用高脂高糖饮食诱导胰岛素抵抗模型。在饮用水中添加2%牛磺酸，探讨牛磺酸抗胰岛素抵抗的机制，为利用牛磺酸改善胰岛素抵抗提供理论依据。口服糖耐量试验结果显示，高脂高糖饮食可降低胰岛素敏感性，牛磺酸可改善胰岛素敏感性。而且高糖高脂饲料喂养的大鼠血清TG、TC较高，而HDL-C低于正常大鼠，给予2%牛磺酸可明显缓解其变化。高糖、高脂饮食显着改变的IRS1、GLUT4 mRNA和蛋白表达也能被2%牛磺酸调节。结果表明，牛磺酸可以通过修复脂质代谢紊乱、调节IRS和GLUT4的表达来提高胰岛素敏感性。
Metabolic syndrome is a lifestyle-related disease caused by high nutrient condition and lack of exercise. The insulin resistance due to obesity has attracted attention as an underlying mechanism of metabolic syndrome. Insulin resistance refers to reduced insulin sensitivity in insulin target tissues. In this case, in order to maintain normal blood glucose levels, a compensatory large amount of insulin is released, leading to the occurrence of hyperinsulinemia. Taurine is widely distributed in animal tissues. Although it is not involved in protein synthesis, taurine plays an important role in maintaining the body’s physiological function. In this experiment, insulin resistance model was induced by high fat and high sugar diet. Two percent taurine was added in drinking water to explore the mechanism of taurine in insulin resistance and to provide theoretical basis for using taurine to improve insulin resistance. The result showed that high-fat and high-sugar diet could decrease insulin sensitivity, and taurine could improve it by oral glucose tolerance test. Moreover, serum TG, TC were higher, while HDL-C in rats fed with high sugar and high fat diet was lower than normal rats, the changes of which can be significantly relieved by 2% taurine administration. mRNA and protein expressions of IRS1, and GLUT4 which were significantly changed by high sugar and high fat diet can also be regulated by 2% taurine. The results indicated that taurine can improve insulin sensitivity through remediating lipid metabolism disorder and regulating the expressions of IRS and GLUT4.