The matrilins:: a novel family of oligomeric extracellular matrix proteins
The matrilins:: a novel family of oligomeric extracellular matrix proteins
复制标题
DOI：
10.1016/s0945-053x(98)00006-7
复制
发表时间：
1999-02-01
期刊：
影响因子：
6.9
通讯作者：
Paulsson, M
中科院分区：
文献类型：
--
作者：
Deák, F;Wagener, R;Paulsson, M
matrilin家族目前有四个成员，它们都具有由von Willebrand因子A结构域、表皮生长因子样结构域和卷曲螺旋α-螺旋模块组成的结构。该家族的第一个成员matrilin-1（以前称为软骨基质蛋白或CMP）主要在软骨中表达。基质蛋白-3具有相似的组织分布，而基质蛋白-2和基质蛋白-4存在于多种细胞外基质中。Matrilin-1与软骨蛋白聚糖相关，并且是胶原依赖性和胶原非依赖性原纤维的组分，并且基于相关结构，其他matrilin可能发挥类似的作用。matrilin基因受到严格和不同的调控，其表达可作为细胞分化的标志。(C)1999年Elsevier Science B.V./国际矩阵生物学学会。All rights reserved.
The matrilin family at present has four members that all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil alpha-helical module. The first member of the family, matrilin-1 (previously called cartilage matrix protein or CMP), is expressed mainly in cartilage. Matrilin-3 has a similar tissue distribution, while matrilin-2 and -4 occur in a wide variety of extracellular matrices. Matrilin-1 is associated with cartilage proteoglycans as well as being a component of both collagen-dependent and collagen-independent fibrils and on the basis of the related structures other matrilins may play similar roles. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation. (C) 1999 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.