ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
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DOI：
10.1016/s0021-9258(17)40754-x
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发表时间：
1994-06
期刊：
影响因子：
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通讯作者：
Benjamin P C Chen;Guosheng Liang;J. Whelan;Tsonwin Hai
中科院分区：
文献类型：
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作者：
Benjamin P C Chen;Guosheng Liang;J. Whelan;Tsonwin Hai
ATF3是哺乳动物激活转录因子/cAMP响应元件结合蛋白（ATF/CREB）转录因子家族的成员。在这篇报告中，我们证明，与它的名字所暗示的相反，ATF3抑制而不是激活具有ATF位点的启动子的转录。我们还提供证据表明，ATF3抑制转录的一种可能机制是稳定启动子处的抑制辅因子。此外，我们描述了一种自然发生的，可选择拼接的ATF3形式：ATF3 delta Zip。ATF3三角洲Zip缺乏亮氨酸拉链结构域，不与DNA结合。与ATF3相反，ATF3三角洲Zip刺激转录，可能是通过隔离抑制辅因子远离启动子。ATF3 delta Zip可能是生理上重要的调节因子，它与ATF3一起调节特定靶基因的表达。
ATF3 is a member of the mammalian activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family of transcription factors. In this report, we demonstrate that, contrary to the implication of its name, ATF3 represses rather than activates transcription from promoters with ATF sites. We also present evidence suggesting that one possible mechanism by which ATF3 represses transcription is to stabilize inhibitory co-factors at the promoter. In addition, we describe a naturally occurring, alternatively spliced, form of ATF3: ATF3 delta Zip. ATF3 delta Zip lacks the leucine zipper domain and does not bind to DNA. In contrast to ATF3, ATF3 delta Zip stimulates transcription, presumably by sequestering inhibitory co-factors away from the promoter. It is possible that ATF3 delta Zip is a physiologically important regulator and that it, together with ATF3, regulates the expression of specific target genes.