Root reconstruction for bladder reinnervation: An experimental study in rats
Root reconstruction for bladder reinnervation: An experimental study in rats
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DOI：
10.1002/micr.1920120403
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发表时间：
1991
期刊：
影响因子：
2.1
通讯作者：
D. Chuang;P. Chang;Shaw‐Yi Cheng
中科院分区：
文献类型：
--
作者：
D. Chuang;P. Chang;Shaw‐Yi Cheng
神经转移（或神经交叉）是一种成熟的技术，用于通过使用价值较低的功能神经重新连接来实现有价值的感觉或运动区域的神经再支配。下段脊髓病变引起神经源性膀胱功能障碍的患者理论上可以从这种恢复有用排尿的方法中受益。基于脊神经的已知解剖细节，创建了一种新的重建方法，以提供用于纯运动到运动神经再支配的硬膜内腹根转移和用于纯感觉到感觉神经再支配的硬膜外节后脊神经转移。在大鼠中进行了实验研究，证明了这种方法的可行性。一种改良的方法，将使用神经移植物的硬膜外途径，纯运动和感觉转移，而不需要广泛的椎板切除术和硬膜开放。预计这种拟议的方法将最大限度地减少与这种脊神经重建相关的发病率和死亡率。
Nerve transfer (or nerve crossover) is a well established technique for achieving reinnervation of a valuable sensory or motor territory by reconnection using a functional nerve of lesser value. Patients with lower spinal cord lesions causing neurogenic bladder dysfunction could theoretically benefit from such an approach for return of useful micturition. Based on the known anatomical details of the spinal nerve, a new reconstructive method was created to provide intradural ventral root transfer for pure motor‐to‐motor reinnervation and extradural postganglionic spinal nerve transfer for pure sensory‐to‐sensory reinnervation. Experimental studies in rats were performed, demonstrating the feasibility of this approach. A modified method is further suggested that would use nerve grafts for extradural approaches to pure motor and sensory transfers, without the need for extensive laminectomy and dura opening. This proposed approach is anticipated to minimize the associated morbidity and mortality with such spinal nerve reconstruction.