Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response
Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response
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DOI：
10.1016/j.bbrc.2021.12.050
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发表时间：
2021-12-20
影响因子：
3.1
通讯作者：
Yamashita, Masakatsu
中科院分区：
文献类型：
--
作者：
Konishi, Amane;Suzuki, Junpei;Yamashita, Masakatsu
糖皮质激素(GC)、免疫抑制药和抗炎药对T细胞有不同的作用。然而，GCs对T细胞介导的免疫反应的长期影响仍有待阐明。我们证明，在TCR介导的激活阶段给予GC会导致糖酵解的长期抑制，即使在GC停用后也是如此。GC激活的CD8T细胞的效应功能获得受到抑制，而PD-1的表达增加。此外，过继转移实验显示，经GC处理的CD8T细胞减少了记忆T细胞的形成和抗肿瘤活性。这些发现表明GCs通过调节T细胞代谢对T细胞介导的免疫反应具有长期的影响。(C)2021年提交人。由爱思唯尔公司出版。这是CC BY-NC-ND许可证(http://creativecommons.org/licenses/by-nc-nd/4.0/).下的一篇开放获取文章
Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have various effects on T cells. However, the long-term influence of GCs on the T cell-mediated immune response remain to be elucidated. We demonstrated that the administration of GC during the TCR-mediated activation phase induced long-lasting suppression of glycolysis, even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while the expression of PD-1 was increased in CD8 T cells activated in the presence of GC. Furthermore, adoptive transfer experiments revealed that GC-treated CD8 T cells reduced memory T cell formation and anti-tumor activity. These findings reveal that GCs have longlasting influence on the T cell-mediated immune response via modulation of T cell metabolism. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).