Somatosensory substrates of flight control in bats.
Somatosensory substrates of flight control in bats.
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DOI：
10.1016/j.celrep.2015.04.001
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发表时间：
2015-05-12
期刊：
影响因子：
8.8
通讯作者：
Lumpkin EA
中科院分区：
文献类型：
--
作者：
Marshall KL;Chadha M;deSouza LA;Sterbing-D'Angelo SJ;Moss CF;Lumpkin EA
飞行动作需要快速的感觉整合，以产生自适应的运动输出。蝙蝠通过改装前肢作为翼型，实现了非凡的灵活性，同时保留了操纵物体的能力。机翼感觉输入提供了指导飞行的行为相关信息；然而，尚未分析机翼感觉-马达回路的组成部分。在这里，我们阐明了食虫性动物--大褐蝙蝠--青叶蝙蝠的翅膀神经组织。我们证明了翅膀感觉神经支配不同于其他脊椎动物的前肢，揭示了蝙蝠躯体感觉核团非典型地形图组织的外周基础。此外，机翼受到一组不同寻常的感觉神经元的支配，这些神经元准备报告气流和触摸。最后，我们报告了皮质神经元编码具有稀疏活动模式的触觉和气流输入。总之，我们的发现确定了蝙蝠翅膀中躯体感觉的神经底物，并暗示导致哺乳动物飞行的进化压力导致了不寻常的感觉运动投射。
Flight maneuvers require rapid sensory integration to generate adaptive motor output. Bats achieve remarkable agility with modified forelimbs that serve as airfoils while retaining capacity for object manipulation. Wing sensory inputs provide behaviorally relevant information to guide flight; however, components of wing sensory-motor circuits have not been analyzed. Here, we elucidate the organization of wing innervation in an insectivore, the big brown bat, Eptesicus fuscus. We demonstrate that wing sensory innervation differs from other vertebrate forelimbs, revealing a peripheral basis for the atypical topographic organization reported for bat somatosensory nuclei. Furthermore, the wing is innervated by an unusual complement of sensory neurons poised to report airflow and touch. Finally, we report that cortical neurons encode tactile and airflow inputs with sparse activity patterns. Together, our findings identify neural substrates of somatosensation in the bat wing and imply that evolutionary pressures giving rise to mammalian flight led to unusual sensorimotor projections.