DENSITY AND ORGANIZATION OF FREE NERVE-ENDINGS IN THE CORNEAL EPITHELIUM OF THE RABBIT
DENSITY AND ORGANIZATION OF FREE NERVE-ENDINGS IN THE CORNEAL EPITHELIUM OF THE RABBIT
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DOI：
10.1016/0304-3959(82)90092-6
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发表时间：
1982-01-01
期刊：
影响因子：
7.4
通讯作者：
BEUERMAN, RW
中科院分区：
文献类型：
--
作者：
ROZSA, AJ;BEUERMAN, RW
尽管在角膜神经支配方面做了大量的工作，但关于角膜上皮内终末的组织和密度的许多问题仍未得到解答。本研究使用了金浸渍兔角膜的光学显微镜观察，记录了假定的，但迄今尚未计算的，上皮内终末的高密度。角膜上皮的神经支配密度约为。是皮肤的300-600倍，牙髓的20-40倍。上皮神经支配密度由角膜中心向周围逐渐降低。在角膜末梢组织设计的三维重建中，采用了连续横切面和平面支架。从上皮下丛，可见轴突穿透上皮，形成垂直和水平分化或分支的终末。垂直轴突向外细胞层延伸。水平轴突发育成带科，末端分支和末端无组织。角膜末梢的密度和组织几何形状，以及它们的解剖独特性与刺激引起的感觉类型之间的相关性，表明角膜是研究实验性急性疼痛的有用模型。
Many questions regarding the organization and the density of corneal intraepithelial terminals remain unanswered in spite of the extensive work that has been done on corneal innervation. This study used light microscopic observations of Au-impregnated, serial cross-sections of rabbit cornea to document the assumed, but hitherto uncalcalated, high density of intraepithelial terminals. The innervation density of corneal epithelium was .apprx. 300-600 times that of skin and 20-40 times that of tooth pulp. The density of epithelial innervation decreased from the center of the cornea to the periphery. Serial cross-sections and flat mounts were used in the 3-dimensional reconstruction of the organizational design of corneal terminals. From the subepithelial plexus, axons were seen to penetrate the epithelium, forming terminals that either diverged or branched vertically and horizontally. The vertical axons extended toward the outer cell layer. Horizontal axons developed into families of leashes with disorganized terminal branches and endings. The density and organizational geometry of corneal terminals, together with the correlations between their anatomical uniqueness and the types of sensations elicited by their stimulation, suggest that the cornea is a useful model for the study of experimental acute pain.