Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization.
Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization.
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DOI：
10.1016/j.ceb.2016.01.004
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发表时间：
2016-02
影响因子：
7.5
通讯作者：
S. Naganathan;T. Middelkoop;S. Fürthauer;S. Grill
中科院分区：
文献类型：
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作者：
S. Naganathan;T. Middelkoop;S. Fürthauer;S. Grill
手性或镜像不对称性是生物学中的一个常见主题，存在于生物体平面图、组织模式甚至单个细胞中。在许多情况下，手性的出现是由肌动蛋白细胞骨架动力学驱动的。虽然已经确定肌动蛋白细胞骨架在分子水平上产生旋转力，但我们才刚刚开始了解这如何导致整个肌动蛋白网络在体内的手性行为。在这篇综述中，我们将概述肌动蛋白驱动的手性在不同的长度尺度，直到今天已知的。此外，我们评估最近的定量模型表明，手性对称性破缺的细胞可以通过适当调整肌动球蛋白细胞骨架中的分子尺度扭矩产生过程来实现。
Chirality or mirror asymmetry is a common theme in biology found in organismal body plans, tissue patterns and even in individual cells. In many cases the emergence of chirality is driven by actin cytoskeletal dynamics. Although it is well established that the actin cytoskeleton generates rotational forces at the molecular level, we are only beginning to understand how this can result in chiral behavior of the entire actin networkin vivo. In this review, we will give an overview of actin driven chiralities across different length scales known until today. Moreover, we evaluate recent quantitative models demonstrating that chiral symmetry breaking of cells can be achieved by properly aligning molecular-scale torque generation processes in the actomyosin cytoskeleton.