Effects of antidromic trigeminal nerve stimulation in relation to parasympathetic vasodilation in cat nasal mucosa.
Effects of antidromic trigeminal nerve stimulation in relation to parasympathetic vasodilation in cat nasal mucosa.
复制标题
逆向三叉神经刺激对猫鼻粘膜副交感血管舒张的影响。
DOI：
10.1111/j.1748-1716.1983.tb07299.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Lundberg
中科院分区：
文献类型：
--
作者：
L. Lundblad;A. Ánggard;J. Lundberg
交感神经切除猫三叉神经的高阈值刺激引起的阿托品和六甲铵抵抗性鼻粘膜血管扩张。刺激传出副交感神经元的鼻子引起了部分阿托品敏感的血管扩张，这是取消了由六甲双铵。联合三叉神经和副交感神经刺激没有发现这两个系统之间的任何明显的功能相互作用。局部动脉灌注P物质、VIP和乙酰胆碱可引起鼻粘膜血管舒张，呈剂量依赖性。P物质对VIP的相对舒张作用大于乙酰胆碱。局部注射辣椒素，已知从神经末梢释放P物质，引起明显的持久的双相血管舒张，这是阿托品和六甲双铵耐药。总之，目前的研究结果说明存在两种不同的神经来源的鼻粘膜血管扩张机制。三叉神经反应可能是通过释放P物质介导的，而副交感神经效应似乎是由乙酰胆碱和VIP引起的。
High threshold stimulation of the trigeminal nerve in sympathectomized cats caused an atropine and hexamethonium resistant vasodilation in the nasal mucosa. Stimulation of efferent parasympathetic neurons to the nose caused a partially atropine sensitive vasodilation which was abolished by hexamethonium. Combined trigeminal and parasympathetic nerve stimulation did not reveal any obvious functional interactions between these two systems. Local intra-arterial infusions of substance P, VIP and acetylcholine caused a dose dependent vasodilation in the nasal mucosa. The relative vasodilatory potencies were substance P greater than to VIP greater than acetylcholine. Local infusions of capsaicin, known to release substance P from nerve endings, caused a marked longlasting biphasic vasodilation which was atropine and hexamethonium resistant. In conclusion, the present findings illustrate the presence of two vasodilator mechanisms of different nervous origin in the nasal mucosa. The trigeminal response is probably mediated via release of substance P, while the parasympathetic effect seems to be caused by acetylcholine and VIP.