Serotonergic receptors and effects in hypoglossal and laryngeal motoneurons semi-quantitative studies in neonatal and adult rats.
Serotonergic receptors and effects in hypoglossal and laryngeal motoneurons semi-quantitative studies in neonatal and adult rats.
复制标题
新生和成年大鼠舌下和喉运动神经元的血清素受体及其影响半定量研究。
DOI：
10.1007/0-387-27023-x_28
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发表时间：
2004
影响因子：
--
通讯作者：
Kubin,Leszek
中科院分区：
文献类型：
--
作者：
Volgin,DenysV;Fenik,VictorB;Fay,Richard;Okabe,Shinichi;Davies,RichardO;Kubin,Leszek
脑干的呼吸运动神经元表达5-羟色胺（5-HT）的多种受体。1 -7这些受体中的一些介导兴奋作用（例如，类型2），而其他（例如，1型）是抑制性的，然而施加到成熟动物的运动神经元上的5-HT的净效应是兴奋，并且内源性多巴胺能效应的拮抗作用抑制脑干呼吸运动神经元的活性。8 -10由于所有脑干多巴胺能神经元在慢波睡眠期间一致地表现出降低的活性并且在快速眼动（REM）睡眠期间沉默，已经提出，脑干呼吸运动神经元的肾上腺素能兴奋的撤回可能在睡眠相关的活动减少中起重要作用。8在上气道解剖异常的个体中，这种减少可能导致夜间上气道阻塞，导致阻塞性睡眠呼吸暂停综合征（参考文献11）。
Respiratory motoneurons of the brainstem express multiple receptors for serotonin (5-HT).1–7 Some of these receptors mediate excitatory effects (e.g., type 2), whereas others (e.g., type 1) are inhibitory, yet the net effect of 5-HT applied onto motoneurons of mature animals is excitation, and antagonism of endogenous serotonergic effects suppresses the activity in brainstem respiratory motoneurons.8–10 Since all brainstem serotonergic neurons consistently exhibit decreased activity during slow-wave sleep and are silenced during rapid eye movement (REM) sleep, it has been proposed that a withdrawal of serotonergic excitation from brainstem respiratory motoneurons may play an important role in sleep-related decrements of their activity.8 In individuals with anatomical abnormalities of their upper airway, such decrements may cause nocturnal upper airway obstructions, leading to the obstructive sleep apnea syndrome (reviewed in ref. 11).