Physiologic vasomotor symptoms are associated with verbal memory dysfunction in breast cancer survivors
Physiologic vasomotor symptoms are associated with verbal memory dysfunction in breast cancer survivors
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DOI：
10.1097/gme.0000000000001608
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发表时间：
2020-11-01
影响因子：
2.7
通讯作者：
Maki, Pauline M.
中科院分区：
文献类型：
--
作者：
Fogel, Jessica;Rubin, Leah H.;Maki, Pauline M.
目的：血管运动症状(VMS)、睡眠障碍和认知主诉在有乳腺癌病史的女性中很常见，并导致生活质量下降。对健康女性的研究表明，通过动态皮肤电导监测仪测量的言语记忆能力与生理性VMS之间存在关联，但通过自我报告与VMS之间没有关联。我们假设我们会在女性乳腺癌患者中发现类似的关联。方法：参与者包括30名女性乳腺癌幸存者(平均年龄52.7岁；26.7%非裔美国人)，患有中到重度VMS，参加了一项更大规模的非激素干预VMS的临床试验。在基线时，参与者完成了对生理VMS的评估，基于动作图的睡眠评估，关于情绪的问卷，以及两项语言记忆测试-逻辑记忆(LM)和加州语言学习测试(CVLT)。使用基线数据，我们进行了多元回归分析，以检验VMS与记忆、控制睡眠和其他因素之间的关联。结果：平均而言，女性报告的VMS占总生理性VMS的46%。生理性VMS的出现频率较高--但未见报道的VMS--与加利福尼亚语言学习测验短延迟自由回忆(r[28]=-0.41，P=0.03)、长延迟自由回忆(r[28]=-0.42，P=0.03)和总聚集性(r[28]=-0.39，P=0.04)的低分显著相关。这些关联与睡眠、情绪和其他因素无关。结论：与其对睡眠的影响无关，VMS可能是乳腺癌女性记忆障碍的可改变的贡献者。这些发现强调了客观测量VMS在认知研究中的重要性。
Objective: Vasomotor symptoms (VMS), sleep disturbance, and cognitive complaints are common among women with a history of breast cancer and contribute to decreased quality of life. Studies in healthy women showed an association between verbal memory performance and physiologic VMS measured with ambulatory skin conductance monitors but not with VMS by self-report. We hypothesized that we would find a similar association in women with breast cancer.Methods: Participants included 30 female breast cancer survivors (mean age 52.7 y; 26.7% African-American) with moderate-to-severe VMS enrolled in a larger clinical trial of a nonhormonal intervention for VMS. At baseline, participants completed assessments of physiologic VMS, actigraphy-based assessments of sleep, questionnaires about mood, and two tests of verbal memory - Logical Memory (LM) and the California Verbal Learning Test (CVLT). Using baseline data, we conducted multivariate regression analyses to examine the association between VMS and memory, controlling for sleep and other factors.Results: On average, women reported 46% of total physiologic VMS. A higher frequency of physiologic VMS - but not reported VMS - was significantly associated with lower scores on the California Verbal Learning Test short-delay free recall (r[28] = -0.41, P = 0.03), long-delay free recall (r[28] = -0.42, P = 0.03), and total clustering, (r[28] = -0.39, P = 0.04). These associations were independent of sleep, mood, and other factors.Conclusions: Independent of their effect on sleep, VMS may be a modifiable contributor to memory difficulties in women with breast cancer. These findings underscore the importance of objective measurement of VMS in cognitive studies.