FoxP2 AND OLFACTION: DIVERGENCE OF FoxP2 EXPRESSION IN OLFACTORY TUBERCLE BETWEEN DIFFERENT FEEDING HABIT BATS
FoxP2 AND OLFACTION: DIVERGENCE OF FoxP2 EXPRESSION IN OLFACTORY TUBERCLE BETWEEN DIFFERENT FEEDING HABIT BATS
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DOI：
10.1556/abiol.64.2013.4.3
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发表时间：
2013-12-01
影响因子：
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通讯作者：
Sun, Y.
中科院分区：
文献类型：
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作者：
Chen, Qi;Wang, Lina;Sun, Y.
FoxP 2是有翼螺旋/叉头类转录因子的成员。尽管FoxP 2被发现与言语和语言特别相关，但该基因的作用更广泛，尚未完全阐明。在这项研究中，我们调查了FoxP 2在不同的饮食习惯的蝙蝠（两个食果物种和三个食虫物种）的大脑中的表达。我们发现FoxP 2在食果物种嗅结节中的表达显著高于食虫物种。食果组和食虫组FoxP 2的表达无明显差异。两种蝙蝠嗅结节中FoxP 2表达的差异表明FoxP 2与嗅结节的相关功能密切相关，提示FoxP 2在嗅结节内的感觉整合中起着重要作用，这种差异可能是食果蝙蝠和食虫蝙蝠摄食行为不同的原因。
FoxP2 is a member of the winged helix/forkhead class of transcription factors. Despite FoxP2 is found to have particular relevance to speech and language, the role of this gene is broader and not yet fully elucidated. In this study, we investigated the expression of FoxP2 in the brains of bats with different feeding habits (two frugivorous species and three insectivorous species). We found FoxP2 expression in the olfactory tubercle of frugivorous species is significantly higher than that in insectivorous species. Difference of FoxP2 expression was not observed within each of the frugivorous or insectivorous group. The diverse expression patterns in olfactory tubercle between two kinds of bats indicate FoxP2 has a close relation with olfactory tubercle associated functions, suggesting its important role in sensory integration within the olfactory tubercle and such a discrepancy of FoxP2 expression in olfactory tubercle may take responsibility for the different feeding behaviors of frugivorous and insectivorous bats.