Health-related quality of life and depression in patients with chronic hepatitis C
Health-related quality of life and depression in patients with chronic hepatitis C
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DOI：
10.1016/s0188-4409(03)00003-1
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发表时间：
2003-03-01
影响因子：
7.7
通讯作者：
Kershenobich, D
中科院分区：
文献类型：
--
作者：
Gallegos-Orozco, JF;Fuentes, AP;Kershenobich, D
背景丙型肝炎是世界范围内肝脏疾病的主要原因。它与健康相关的生活质量（HRQL）和精神症状下降有关。我们的目的是评估既往未接受干扰素治疗的慢性丙型肝炎患者的HRQL、抑郁和疾病理解。参加转诊中心的连续性患者入组。采用SF-36问卷、Zung抑郁自评量表、疾病认知自评量表测量HRQL。在入组的157例患者中，112例为女性（71%），45例为男性（29%）。97例患者（61.8%）有肝硬化。在SF-36的所有8个领域中，慢性丙型肝炎患者的HRQL均显著低于历史正常对照组（P < 0.001）。在丙型肝炎患者中，Child-Pugh B级和C级受试者在反映身体健康的领域中的HRQL显著较低（p < 0.05）。92例（58.6%）患者有抑郁，导致HRQL低于非抑郁患者（P < 0.05）。114例（72.6%）患者对丙型肝炎的疾病认识不足。与对疾病有较好理解的患者相比，这些受试者在SF-36 8个领域中的6个领域的HRQL评分显著降低（p < 0.05）。参加三级转诊中心的慢性丙型肝炎患者与抑郁（58.6%）和疾病理解差（72.6%）相关的HRQL显著降低。教育计划及其对HRQL的影响需要详细说明，特别是在治疗前的情况下。(C)2003年IMSS。出版社：Elsevier Science Inc.
Background. Hepatitis C is a major cause of liver disease worldwide. It has been associated with decreased health-related quality of life (HRQL) and psychiatric symptoms. Our aim was to assess HRQL, depression, and illness understanding in patients with chronic hepatitis C without previous interferon therapy.Methods. Consecutive patients attending a referral center were enrolled. HRQL was measured using SF-36 questionnaire, depression with Zung self-rating depression scale, and illness understanding with self-applied knowledge test.Results. Of 157 patients enrolled, 112 were female (71%) and 45 male (29%). Ninety-seven patients (61.8%) had cirrhosis. HRQL was significantly decreased in chronic hepatitis C patients compared to historical normal controls in all eight domains of the SF-36 (P < 0.001). In hepatitis C cirrhotic patients, HRQL was significantly lower among Child-Pugh class B and C subjects in domains reflecting physical health (p < 0.05). Ninety-two patients (58.6%) had depression that resulted in lower HRQL when compared to nondepressed patients (P < 0.05). One hundred fourteen patients (72.6%) had poor illness understanding of hepatitis C. These subjects had significantly lower HRQL scores in six of eight SF-36 domains when compared to patients with better understanding of the disease (p < 0.05).Conclusions. Chronic hepatitis C patients attending a tertiary-referral center had significant decrease in HRQL associated with depression (58.6%) and poor illness understanding (72.6%). Educational programs and their impact on HRQL need to be addressed in detail, particularly for the pre-treatment scenario. (C) 2003 IMSS. Published by Elsevier Science Inc.