A Point-Scoring System for the Clinical Diagnosis of Sjögren's Syndrome Based on Quantified SPECT Imaging of Salivary Gland.
A Point-Scoring System for the Clinical Diagnosis of Sjögren's Syndrome Based on Quantified SPECT Imaging of Salivary Gland.
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DOI：
10.1371/journal.pone.0155666
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Dong L
中科院分区：
文献类型：
--
作者：
Chen J;Zhao X;Liu H;Zhou S;Yang Y;Li S;Xianyu Z;Han Y;Shen G;Li J;Ye C;Sun W;Dong L
建立基于唾液腺SPECT定量显像的干燥综合征(SS)计分诊断系统，并与2002年AECG标准和2012年ACR标准进行比较，评价其可行性和性能。213例疑似SS患者纳入本研究。收集所有患者的相关临床资料。以风湿科专科医生治疗后随访为统一标准，对所有患者进行临床评估和分组(SS组149例，NSS组)。根据唾液腺SPECT显像，计算双侧腮腺和颌下腺的Tmax、UImax、Ts和EFS，并进行组间比较。在唾液腺SPECT定量显像的基础上，建立SS的积分诊断系统。我们评估了新诊断系统的敏感度、特异度、阳性预测值(PPV)、阴性预测值(NPV)和准确性，并与2002年的AECG标准和2012年的ACR标准进行了比较。以7.0为界值，新评分系统诊断SS的敏感度为89.93%，特异度为93.75%，PPV为97.10%，NPV为80.00%，准确度为91.08%(194/213)。新的唾液腺SPECT定量积分诊断系统与2002年AECG和2012年ACR标准相比，保持了特异度，但敏感度显著提高(P<；0.01)。基于唾液腺SPECT定量显像的SS积分诊断系统可能优于2002年的AECG标准和2012年的ACR标准，对SS的诊断具有更高的敏感性和相似的特异性。此外，它在临床环境中也具有良好的可行性。
To establish a point-scoring diagnostic system for Sjögren's syndrome (SS) based on quantified SPECT imaging of salivary gland, and evaluate its feasibility and performance compared with 2002 AECG criteria and 2012 ACR criteria. 213 patients with suspected SS enrolled in this study. The related clinical data of all patients were collected. All patients were evaluated and grouped on a clinical basis and posttreatment follow-up by rheumatology specialists as the unified standard (SS group with 149 cases and nSS group with 64 cases). From SPECT imaging of salivary gland, Tmax, UImax, Ts and EFs were derived for bilateral parotid and submandibular glands, and compared between the groups. A point-scoring diagnostic system for SS was established based on the quantified SPECT imaging of salivary gland. We estimated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for the new diagnostic system, compared with 2002 AECG criteria and 2012 ACR criteria. When 7.0 was used as the cut-off point, the sensitivity, specificity, PPV, NPV and accuracy for the new point-scoring system in diagnosing SS were 89.93% (134/149), 93.75% (60/64), 97.10% (134/138), 80.00% (60/75) and 91.08% (194/213), respectively. The new point-scoring diagnostic system based on quantified SPECT imaging of salivary gland keeps the specificity comparatively to 2002 AECG criteria and 2012 ACR criteria, but improves the sensitivity significantly (P<0.01). The new point-scoring diagnostic system for SS based on quantified SPECT imaging of salivary gland may be superior to 2002 AECG criteria and 2012 ACR criteria, with higher sensitivity and similar specificity in the diagnosis of SS. Additionally, it also has good feasibility in the clinical settings.