Auditory tuning for spatial cues in the barn owl basal ganglia.
Auditory tuning for spatial cues in the barn owl basal ganglia.
复制标题
谷仓猫头鹰基底神经节空间线索的听觉调谐。
DOI：
10.1152/jn.1994.72.1.285
复制
发表时间：
1994
影响因子：
2.5
通讯作者：
Knudsen,EI
中科院分区：
文献类型：
--
作者：
Cohen,YE;Knudsen,EI
1.已知基底神经节有助于空间引导行为。在这项研究中，我们调查了仓鸮paleostriatum augmentum（PA），同源的哺乳动物纹状体神经元的听觉反应特性。这些数据表明，仓鸮PA是专门处理空间线索，像哺乳动物纹状体，参与空间行为。2.单单位和多单位的网站记录在细胞外氯胺酮麻醉的猫头鹰。用自由场声源测量空间感受野，并使用数字合成的双耳分听刺激评估频率和耳间时间差（ITD）和水平（ILD）的调谐。3.在9个多单元站点测量的空间感受野被调谐到有限的空间区域：半最大响应的调谐宽度平均为22 +/- 9.6度（平均值+/- SD）的方位角和54 +/- 22度的仰角。4. PA网站对宽带声音反应强烈。当频率调谐可以测量（n = 145/201网站），调谐是广泛的，平均2.7 kHz的半最大响应，并往往集中在高端附近的猫头鹰的可听范围。平均最佳频率为6.2 kHz。5.所有PA部位（n = 201）对ITD和ILD均具有选择性。ITD调谐曲线通常在ITD的同侧和/或对侧呈现单个大的“主”峰和通常较小的“次”峰。三个指标量化的选择性PA网站ITD。第一个指数是作为ITD函数的最小和最大反应之间的百分比差异，平均为100 +/-29%。第二个指数代表最大次峰相对于主峰的大小，平均为49 +/-23%。第三个指标是ITD主峰在半最大响应时的宽度，平均值仅为66 +/- 35微秒。6.大多数（96%; n = 192/201）PA部位被调整为ILD的单一“最佳”值。ILD调谐曲线在半最大响应处的宽度平均为24 +/- 9 dB。7.平均而言，声级对场地的最佳ITD或最佳ILD没有影响，也不影响ITD调谐宽度。然而，ILD调谐宽度确实倾向于随着声级略微增加（平均效应为0.1 dB ILD/dB）。8.大多数PA站点对对侧耳引导ITD的响应最好，其中大多数被调谐到接近0微秒的ITD（对应于中线对侧的声源位置）。（400字处截断摘要）
1. The basal ganglia are known to contribute to spatially guided behavior. In this study, we investigated the auditory response properties of neurons in the barn owl paleostriatum augmentum (PA), the homologue of the mammalian striatum. The data suggest that the barn owl PA is specialized to process spatial cues and, like the mammalian striatum, is involved in spatial behavior. 2. Single- and multiunit sites were recorded extracellularly in ketamine-anesthetized owls. Spatial receptive fields were measured with a free-field sound source, and tuning for frequency and interaural differences in timing (ITD) and level (ILD) was assessed using digitally synthesized dichotic stimuli. 3. Spatial receptive fields measured at nine multiunit sites were tuned to restricted regions of space: tuning widths at half-maximum response averaged 22 +/- 9.6 degrees (mean +/- SD) in azimuth and 54 +/- 22 degrees in elevation. 4. PA sites responded strongly to broadband sounds. When frequency tuning could be measured (n = 145/201 sites), tuning was broad, averaging 2.7 kHz at half-maximum response, and tended to be centered near the high end of the owl's audible range. The mean best frequency was 6.2 kHz. 5. All PA sites (n = 201) were selective for both ITD and ILD. ITD tuning curves typically exhibited a single, large “primary” peak and often smaller, “secondary” peaks at ITDs ipsilateral and/or contralateral to the primary peak. Three indices quantified the selectivity of PA sites for ITD. The first index, which was the percent difference between the minimum and maximum response as a function of ITD, averaged 100 +/- 29%. The second index, which represented the size of the largest secondary peak relative to that of the primary peak, averaged 49 +/- 23%. The third index, which was the width of the primary ITD peak at half-maximum response, averaged only 66 +/- 35 microseconds. 6. The majority (96%; n = 192/201) of PA sites were tuned to a single “best” value of ILD. The widths of ILD tuning curves at half-maximum response averaged 24 +/- 9 dB. 7. On average, sound level had no effect on a site's best ITD or best ILD nor did it affect ITD tuning widths. ILD tuning widths did, however, tend to increase slightly with sound level (average effect was 0.1 dB ILD/dB). 8. Most PA sites responded best to contralateral-ear leading ITDs with a majority being tuned to ITDs near 0 microsecond (corresponding to sound-source locations just contralateral to the midline).(ABSTRACT TRUNCATED AT 400 WORDS)