MOLECULAR STRUCTURE AND SOME TRANSPORT PROPERTIES OF VALINOMYCIN
MOLECULAR STRUCTURE AND SOME TRANSPORT PROPERTIES OF VALINOMYCIN
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DOI：
10.1016/0006-291x(69)90376-3
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发表时间：
1969-01-01
影响因子：
3.1
通讯作者：
DAWKINS, P
中科院分区：
文献类型：
--
作者：
PINKERTON, M;STEINRAUF, LK;DAWKINS, P
众所周知，抗生素缬氨霉素会影响线粒体系统的离子转运行为。我们已经确定了分子结构的X-射线晶体学的环十二缩酚酸肽的钾aurichloride复合物，并发现它被包裹在钾离子协调的氧原子交替羰基，保持在一起的氢键，并持有阴离子较少具体。我们建立了一个扩散装置，用它可以证明缬氨霉素的阴-阳离子传输特性。一个方程给出的平衡状态。
The antibiotic valinomycin is well known to affect the ion transport behavior of mitochondrial systems. We have determined the molecular structure by X-ray crystallography of this cyclododecadepsipeptide as the potassium aurichloride complex, and find it to be wrapped around the potassium ion coordinated to the oxygen atoms of alternate carbonyl groups, held together by hydrogen bonding, and holding the anion less specifically. We have constructed a diffusion apparatus with which the anion-cation transporting properties of valinomycin can be demonstrated. An equation is given for the equilibrium situation.