Abnormally increased intramuscular pressure in human legs: Comparison of two experimental models
Abnormally increased intramuscular pressure in human legs: Comparison of two experimental models
复制标题
DOI：
10.1097/00005373-199807000-00028
复制
发表时间：
1998-07-01
影响因子：
--
通讯作者：
Wiger, P
中科院分区：
文献类型：
--
作者：
Styf, J;Wiger, P
背景：10例受试者20条小腿的前室压力异常升高是通过对侧小腿静脉淤血和对侧小腿圆柱形空气夹板外压引起的。结果：静脉瘀血时肌内压升高至38.9 mm Hg(SD=2.9)，外按压时为39.8 mm Hg(SD=1.6)，差异无统计学意义。当双腿抬高时，前室的血液灌流压显著下降到25 mm Hg。受试者仅在管型阻塞小腿的足部出现感觉丧失和肌肉无力。结论：管型高位小腿静脉淤滞是一种可替代的实验模型，可导致人体小腿肌肉内压异常升高和神经肌肉功能障碍。静脉瘀血模型在模拟急性脑室间隔综合征的发病机制和病理生理研究中可能比外按压更好。
Background: Abnormally increased pressure in the anterior compartment of 20 legs in 10 subjects was induced by applying venous stasis of a casted leg and external compression by a cylindrical air splint of the contralateral leg. The effects of increased intramuscular pressure (IMP) on blood perfusion pressure and clinical symptoms in the foot were compared during 30 minutes by the two methods.Results: Intramuscular pressure increased to 38.9 (SD = 2.9) mm Hg when venous stasis was applied and to 39.8 (SD = 1.6) by external compression (not significant). Blood perfusion pressure in the anterior compartment decreased significantly to 25 mm Hg in both legs when they were elevated. Subjects experienced loss of sensation and muscular weakness only in the foot of the casted obstructed leg.Conclusions: Venous stasis of a casted elevated leg is an alternative experimental model to induce abnormally increased intramuscular pressure and neuromuscular dysfunction in the human leg. The venous stasis model may be better than external compression in the study of pathogenesis and pathophysiology of simulated imminent acute compartment syndrome in man.