Brain-derived neurotrophic factor is reduced in Alzheimer's disease
Brain-derived neurotrophic factor is reduced in Alzheimer's disease
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DOI：
10.1016/s0169-328x(97)00125-3
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发表时间：
1997-10-03
期刊：
影响因子：
--
通讯作者：
Dragunow, M
中科院分区：
文献类型：
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作者：
Connor, B;Young, D;Dragunow, M
阿尔茨海默病可能是由于神经营养蛋白或受体表达的缺乏。与这一假说相符的是，在人类死后的阿尔茨海默病海马体中已观察到脑源性神经营养因子（BDNF）mRNA表达的降低。为了进一步研究这一观察结果，我们利用免疫组织化学技术检测了在人类死后的阿尔茨海默病海马体和颞叶皮质中，BDNF表达的改变是否也发生在蛋白质水平。我们观察到，与正常组织相比，阿尔茨海默病海马体和颞叶皮质中BDNF免疫反应性细胞体的强度和数量均降低。这些结果支持并扩展了先前的发现，即人类阿尔茨海默病海马体和颞叶皮质中BDNF mRNA降低，并表明BDNF的缺失可能导致阿尔茨海默病中神经元的进行性萎缩。（C）1997年爱思唯尔科学出版社（Elsevier Science B.V.）
Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has been observed in human post-mortem Alzheimer's disease hippocampi. To further investigate this observation, we examined whether the alteration in BDNF expression also occurred at the protein level in human post-mortem Alzheimer's disease hippocampi and temporal cortices using immunohistochemical techniques. We observed a reduction in the intensity and number of BDNF-immunoreactive cell bodies within both the Alzheimer's disease hippocampus and temporal cortex when compared to normal tissue. These results support and extend previous findings that BDNF mRNA is reduced in the human Alzheimer's disease hippocampus and temporal cortex, and suggest that a loss of BDNF may contribute to the progressive atrophy of neurons in Alzheimer's disease. (C) 1997 Elsevier Science B.V.