Classical conditioning of rabbits 2-1/2 to 4 years old using mossy fiber stimulation as a CS.
Classical conditioning of rabbits 2-1/2 to 4 years old using mossy fiber stimulation as a CS.
复制标题
使用苔藓纤维刺激作为 CS 对 2-1/2 至 4 岁的兔子进行经典调理。
DOI：
10.1016/s0197-4580(88)80049-6
复制
发表时间：
1988
影响因子：
4.2
通讯作者：
Thompson,RF
中科院分区：
文献类型：
--
作者：
Woodruff-Pak,DS;Steinmetz,JE;Thompson,RF
A basic issue in age-related deterioration in memory formation concerns the locus of the age changes. Changes in peripheral portions of the auditory CS pathway could account for the observed age differences in classical conditioning in rabbits. We bypassed peripheral portions of the CS pathway and input the CS more centrally by electrical microstimulation of mossy fibers in the pons. New Zealand White rabbits aged 2−1/2-4 years were compared to six 3-month-old control rabbits with electrode implantations in comparable areas. Training consisted of 108 trials per day in which stimulation CS was paired with a corneal airpuff US. Older rabbits took almost five times as long to condition as the young animals. Thus, age differences in eyelid classical conditioning cannot be entirely attributed to changes in the peripheral CS pathway. Changes in the nervous system occurring more centrally in the cerebellum appear to affect learning and memory.
