Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography.
Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography.
复制标题
用正电子发射断层扫描检查听觉诱发电位响度依赖性的基础。
DOI：
10.1016/j.neuroimage.2020.116733
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发表时间：
2020
期刊：
影响因子：
5.7
通讯作者：
DeLorenzo,Christine
中科院分区：
文献类型：
--
作者：
Pillai,RajapillaiLI;Bartlett,ElizabethA;Ananth,MalaR;Zhu,Chencan;Yang,Jie;Hajcak,Greg;Parsey,RaminV;DeLorenzo,Christine
听觉诱发电位（LDAEP）的响度依赖性长期以来被认为反映了中枢基础血清素传递。然而，LDAEP与个体血清素受体和转运体之间的关系尚未在人类中得到充分探讨，可能涉及其他神经递质系统。为了研究LDAEP与血清素系统的关系，我们通过[11C]CUMI-101使用5-羟色胺- 1a （5-HT1A）成像和[11C]DASB使用5-羟色胺转运体（5-HTT）成像对健康对照（n = 4,4名女性，0名男性）、单极（MDD, n = 11:4名女性，7名男性）和双相抑郁症（BD, n = 8,4名女性，4名男性）的混合样本进行了PET检测。对这些参与者，我们也在PET扫描的一周内进行了脑电图（EEG），使用不同强度的1000 Hz音调来唤起LDAEP。然后，我们评估了LDAEP与中脑(5-HT1A)/中脑（5-HTT）区域和颞叶皮层中5-HT1Aor 5-HTT结合之间的关系。我们发现LDAEP与5- ht1在颞叶皮层呈显著正相关，与5- ht1呈显著负相关（p < 0.05），而与中脑和中脑无相关。仅在男性中，探索性分析显示LDAEP与5- ht1a在整个大脑的多个区域显著相关；我们在5-HTT中没有发现这一点。这项多模式研究部分验证了血清素对LDAEP影响的临床前模型。在更大的样本中进行复制是必要的，以进一步阐明我们对血清素在听觉音调感知中的作用的理解。
Loudness dependence of auditory evoked potentials (LDAEP) has long been considered to reflect central basal serotonin transmission. However, the relationship between LDAEP and individual serotonin receptors and transporters has not been fully explored in humans and may involve other neurotransmitter systems. To examine LDAEP’s relationship with the serotonin system, we performed PET using serotonin-1A (5-HT1A) imaging via [11C]CUMI-101 and serotonin transporter (5-HTT) imaging via [11C]DASB on a mixed sample of healthy controls (n = 4: 4 females, 0 males), patients with unipolar (MDD, n = 11: 4 females, 7 males) and bipolar depression (BD, n = 8: 4 females, 4 males). On these same participants, we also performed electroencephalography (EEG) within a week of PET scanning, using 1000 Hz tones of varying intensity to evoke LDAEP. We then evaluated the relationship between LDAEP and 5-HT1Aor 5-HTT binding in both the raphe (5-HT1A)/midbrain (5-HTT) areas and in the temporal cortex. We found that LDAEP was significantly correlated with 5-HT1Apositively and with 5-HTT negatively in the temporal cortex (p < 0.05), but not correlated with either in midbrain or raphe. In males only, exploratory analysis showed multiple regions in which LDAEP significantly correlated with 5-HT1Athroughout the brain; we did not find this with 5-HTT. This multimodal study partially validates preclinical models of a serotonergic influence on LDAEP. Replication in larger samples is necessary to further clarify our understanding of the role of serotonin in perception of auditory tones.