Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists
Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists
复制标题
低钠血症：诊断、并发症和治疗，包括 V2 受体拮抗剂
DOI：
10.1097/mnh.0b013e3283436f14
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发表时间：
2011
影响因子：
3.2
通讯作者：
R. Schrier
中科院分区：
文献类型：
--
作者：
E. Elhassan;R. Schrier
Purpose of reviewRecent studies have consistently demonstrated the common prevalence of hyponatremia in the hospital and intensive care settings, and how it correlates with untoward outcomes. This review discusses the classification, diagnosis, and pathophysiology of hyponatremia and how these agents may influence its management, and also examines the available treatment options and their weaknesses and strengths. Recent findingsThis review is timely and relevant, as mild degrees of serum sodium lowering may be associated with adverse neurologic and musculoskeletal effects. These findings have the potential to transform our approach to managing hyponatremia. A major advance in our ability to treat hyponatremia was the introduction and approval of aquaretics (vaptans). Emerging data on vaptans and their potential role to treat hyponatremia in the settings of the syndrome of inappropriate antidiuretic hormone secretion, congestive heart failure, and liver cirrhosis are presented. SummaryVaptans will likely play an important role in treating hyponatremia, given their clinical effectiveness and tolerability. Cost remains a hindrance for vaptans, and more studies are needed to further define their best utilization in hyponatremic patients.
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影响因子：
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作者：
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影响因子：
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