Multifunctional Artificial Artery from Direct 3D Printing with Built-In Ferroelectricity and Tissue-Matching Modulus for Real-Time Sensing and Occlusion Monitoring
Multifunctional Artificial Artery from Direct 3D Printing with Built-In Ferroelectricity and Tissue-Matching Modulus for Real-Time Sensing and Occlusion Monitoring
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DOI：
10.1002/adfm.202002868
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发表时间：
2020-07-21
影响因子：
19
通讯作者：
Wang, Xudong
中科院分区：
文献类型：
--
作者：
Li, Jun;Long, Yin;Wang, Xudong
治疗血管移植失败需要复杂的外科手术，并且风险很高。实时监测血管系统能够快速可靠地识别并发症，并尽早启动更安全的治疗。在这里，开发了一种电场辅助3D打印技术，用于制造原位极化的铁电人工动脉，提供无电池的实时血压传感和闭塞监测能力。功能性动脉结构通过铁电生物复合材料的开发而成为可能，该铁电生物复合材料可以在打印过程中快速极化并重塑为设计的物体。钾钠亚磷酸盐颗粒和聚偏二氟乙烯聚合物基质的协同效应产生了极好的压电性能（整体规模（33）> 12 pC N-1）。正弦结构使机械模量接近血管水平。人造动脉的所需压电和机械性能提供了对人血压（11.25-225.00 mmHg）范围内的压力变化（0.306 mV mmHg（-1），R-2 > 0.99）的优异灵敏度。高压力灵敏度和检测细微血管运动模式变化的能力使得能够早期检测部分闭塞（例如，血栓形成），从而允许防止移植物失败。这项工作展示了将多功能纳入智能医疗保健系统的人工生物系统的有前途的策略。
Treating vascular grafts failure requires complex surgery procedures and is associated with high risks. A real-time monitoring vascular system enables quick and reliable identification of complications and initiates safer treatments early. Here, an electric fieldassisted 3D printing technology is developed to fabricate in situ-poled ferroelectric artificial arteries that offer battery-free real-time blood pressure sensing and occlusion monitoring capability. The functional artery architecture is made possible by the development of a ferroelectric biocomposite which can be quickly polarized during printing and reshaped into devised objects. The synergistic effect from the potassium sodium niobite particles and the polyvinylidene fluoride polymer matrix yields a superb piezoelectric performance (bulk-scaled(33) > 12 pC N-1). The sinusoidal architecture brings the mechanical modulus close to the level of blood vessels. The desired piezoelectric and mechanical properties of the artificial artery provide an excellent sensitivity to pressure change (0.306 mV mmHg(-1),R-2 > 0.99) within the range of human blood pressure (11.25-225.00 mmHg). The high pressure sensitivity and the ability to detect subtle vessel motion pattern change enable early detection of partial occlusion (e.g., thrombosis), allowing for preventing grafts failure. This work demonstrates a promising strategy of incorporating multifunctionality to artificial biological systems for smart healthcare systems.