Relationship between Polyunsaturated Fatty Acids and Inflammation: evidence from cohort and Mendelian randomization analyses
Relationship between Polyunsaturated Fatty Acids and Inflammation: evidence from cohort and Mendelian randomization analyses
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多不饱和脂肪酸与炎症之间的关系：来自队列和孟德尔随机分析的证据
DOI：
10.1101/2023.11.27.23299099
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Crick D
中科院分区：
文献类型：
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作者：
Crick D
饮食中的多不饱和脂肪酸(PUFAs)被认为通过调节全身炎症来影响各种慢性病的风险。Omega-3和omega-6脂肪酸被认为分别具有抗炎和促炎作用，但尚不清楚这些联系是否存在因果关系。我们在一个人群队列(n=2748)中，使用孟德尔随机化分析(一种遗传因果推断方法)，测试了多不饱和脂肪酸与三种基于血液的全身炎症生物标志物，即C-反应蛋白(CRP)、糖蛋白乙酰(GlycA)和白介素6(IL-6)的相关性。我们提供了一致的证据，表明omega-6多不饱和脂肪酸增加了GlycA水平，但omega-3脂肪酸并不降低炎症标志物的水平。此外，我们发现，在队列分析中，较高的omega-6：omega-3比率会增加所有三种炎症标志物的水平：CRP(平均差值=0.17；95%CI=0.13，0.20)、GlycA(平均差值=0.16；95%CI=0.13，0.20)和IL-6(平均差值=0.19；95%CI=0.15，0.22)。我们的发现表明，未来的公共卫生信息应该鼓励减少omega 6 FA的消费，并在omega 3和omega 6 FA之间保持健康的平衡，而不是专注于omega-3 FA的补充。这是因为单靠饮食补充omega-3不太可能有助于减少全身炎症或炎症相关疾病。
Dietary polyunsaturated fatty acids (PUFAs) are thought to influence the risk of various chronic diseases by modulating systemic inflammation. Omega-3 and omega-6 FAs are thought to have anti- and pro-inflammatory roles, respectively, but it is unclear whether these associations are causal. We tested associations of PUFAs with three blood-based biomarkers of systemic inflammation, namely C-reactive protein (CRP), glycoprotein acetyls (GlycA) and interleukin 6 (IL-6), in a population cohort (n=2748) and using Mendelian randomization analysis (a genetic causal inference method). We provide consistent evidence that omega-6 PUFAs increase GlycA levels, but omega-3 FAs do not lower levels of inflammatory markers. Additionally, we found that a higher omega-6:omega-3 ratio increases levels of all three inflammatory markers; CRP (mean difference=0.17; 95% CI=0.13, 0.20), GlycA (mean difference=0.16; 95% CI=0.13, 0.20) and IL-6 (mean differene=0.19; 95% CI=0.15, 0.22) in the cohort analysis. Our findings suggest that future public health messaging should encourage reducing the consumption of omega 6 FAs and maintaining a healthy balance between omega 3 and omega 6 FAs, rather than focusing on omega-3 FA supplementation. This is because dietary omega-3 supplementation alone is unlikely to help reduce systemic inflammation or inflammation-related disease.