Prevalence of chronic kidney disease and associated factors in senegalese populations: a community-based study in saint-louis.
Prevalence of chronic kidney disease and associated factors in senegalese populations: a community-based study in saint-louis.
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DOI：
10.5812/numonthly.19085
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发表时间：
2014-09
影响因子：
--
通讯作者：
Dia CA
中科院分区：
文献类型：
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作者：
Seck SM;Doupa D;Gueye L;Dia CA
慢性肾脏病（CKD）是一种新兴的全球性流行病，但关于非洲人群的数据很少.我们的目的是评估塞内加尔北方圣路易市成年人群中CKD的患病率。在2012年1月至5月的一项基于人群的调查中，我们纳入了1037名居住在圣路易斯的≥ 18岁的成年人。在家庭访问期间收集社会人口统计学、临床和生物学数据。采用Jaffé法测定血清肌酐。我们使用四变量肾脏疾病饮食改良（MDRD）方程估计肾小球滤过率（eGFR），CKD定义为eGFR< 60 mL/min/1.73 m2和/或白蛋白尿> 1 g/L。进行多变量logistic回归以确定与CKD相关的因素。参与者的平均年龄为47.9 ± 16.9岁（范围，18-87岁），性别比例（男性对女性）为0.52。大多数参与者居住在城市地区（55.3%），并接受过学校教育（65.6%）。高血压、糖尿病和肥胖分别占39.1%、12.7%和23.4%。总体CKD患病率为4.9%（95% CI，3.5-6.2），0.9%的患者eGFR< 30 mL/min/1.73 m2。3.5%的患者出现白蛋白尿> 1 g/L。CKD在高血压患者中的发生率明显高于血压正常者。与CKD相关的风险因素是高血压（12%的风险超额）和年龄（3%的风险超额）。慢性肾脏病在生活在塞内加尔北方的成年人群中很常见。主要的相关因素是高血压和年龄。迫切需要采取预防策略，提高公众意识，促进城市和农村地区CKD的早期发现和治疗。
Chronic kidney disease (CKD) is an emerging worldwide epidemic but littledata concerning African populations are available. We aimed to assess prevalence of CKD in adult populations of Saint-Louis, northern Senegal. In a population-based survey between January and May 2012, we included 1037 adults ≥ 18 years of age who resided in Saint-Louis. Socio-demographic, clinical, and biologic data were collected during household visits. Serum creatinine was measured by Jaffé method. We estimated glomerular filtration rate (eGFR) using the four-variable Modification of Diet in Renal Disease (MDRD) equation and CKD was defined by eGFR< 60 mL/min/1.73 m2 and/or albuminuria > 1 g/L. A multivariate logistic regression was performed to identify factors associated with CKD. The mean of participants’ age was 47.9 ± 16.9 years (range, 18-87) and sex ratio (male to female) was 0.52. Majority of participants lived in urban areas (55.3%) and had school education (65.6%). Hypertension, diabetes, and obesity were present respectively in 39.1%, 12.7%, and 23.4% of participants. Overall CKD prevalence was 4.9% (95% CI, 3.5-6.2) with eGFR< 30 mL/min/1.73 m2 in 0.9%. Albuminuria > 1 g/L was found in 3.5% of patients. CKD was significantly more frequent among hypertensive patients in comparison with normotensive ones. Risk factors associated with CKD were hypertension (12% of risk excess) and age (3% of risk excess). CKD is frequent in adult population living in Northern Senegal. Main associated factors are hypertension and age. Prevention strategies are urgently needed to raise public awareness and promote early CKD detection and treatment in both urban and rural areas.