Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids
Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids
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DOI：
10.2174/09298673113209990160
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发表时间：
2013-12-01
影响因子：
4.1
通讯作者：
Joshi, S.
中科院分区：
文献类型：
--
作者：
D'Souza, V.;Chavan-Gautam, P.;Joshi, S.
在妊娠期间，氧化应激与先兆子痫和早产的病理生理学有关，导致不良的出生结局。由叶酸和维生素B-12等微量营养素改变引起的高同型半胱氨酸血症与产生氧化应激的活性氧物质的产生增加有关。这些微量营养素是甲基供体S-腺苷甲硫氨酸的重要决定因素，而磷脂是一碳代谢循环中重要的甲基受体。我们对怀孕妇女的一系列研究表明，这些微量营养素的水平发生了变化，二十二碳六烯酸与同型半胱氨酸呈负相关。各种策略，以抵消氧化应激在怀孕期间，如抗氧化剂治疗已被检查，发现是不一致的。在这篇综述中，我们专注于氧化应激在妊娠中的作用，并讨论通过调节母体微量营养素和ω 3脂肪酸，特别是二十二碳六烯酸来改善它的可能性。我们首次提出，通过母体饮食控制一碳代谢可能是一种潜在的机制，通过降低同型半胱氨酸来抵消氧化应激，并有助于降低不良妊娠结局的风险。
During pregnancy, oxidative stress has been implicated in the pathophysiology of preeclampsia and preterm birth leading to poor birth outcome. Hyperhomocysteinemia caused as a consequence of altered micronutrients like folic acid and vitamin B-12 is associated with increased production of reactive oxygen species that generate oxidative stress. These micronutrients are important determinants of methyl donor, s-adenosyl methionine while phospholipids are important methyl acceptors in the one-carbon metabolic cycle. A series of our studies in women during pregnancy have demonstrated altered levels of these micronutrients and the negative association of docosahexaenoic acid with homocysteine. Various strategies to counteract oxidative stress during pregnancy such as antioxidant therapy have been examined and found to be inconsistent. In this review, we focus on the role of oxidative stress in pregnancy and discuss the possibility of ameliorating it through modulation of maternal micronutrients and omega 3 fatty acids especially docosahexaenoic acid. We propose for the first time that manipulation of one-carbon metabolism by maternal diet could be a potential mechanism to counteract oxidative stress through homocysteine lowering effects and help in reducing the risk for adverse pregnancy outcomes.