Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update.
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update.
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心力衰竭和心血管疾病中 Galectin-3 的激活和抑制：最新进展。
DOI：
10.7150/thno.22196
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发表时间：
2018
期刊：
影响因子：
12.4
通讯作者：
de Boer RA
中科院分区：
文献类型：
--
作者：
Suthahar N;Meijers WC;Silljé HHW;Ho JE;Liu FT;de Boer RA
半乳糖凝集素-3是一种多功能蛋白质，在人体内协调几种生理和病理生理过程。在过去的十年中，由于半乳糖凝集素-3作为生物靶标的潜在作用，已经出现了相当大的兴趣。半乳糖凝集素-3根据组织类型差异表达，然而其表达可在组织损伤或应激条件下诱导。半乳糖凝集素-3过表达和分泌与几种疾病有关，并在纤维化、心力衰竭、动脉粥样硬化和糖尿病的背景下被广泛研究。单体（细胞外）半乳糖凝集素-3通常经历进一步的“活化”，这主要通过修饰其碳水化合物结合特性来显著拓宽生物活性谱。这种蛋白的自我相互作用似乎在调节这种蛋白的细胞外活动中起着至关重要的作用，但是关于所涉及的机制的数据有限且有争议。因此，我们总结了（最近）在这方面的文献，并从结合的角度描述半乳糖凝集素-3提供新的见解的机制，其中半乳糖凝集素-3是已知的“激活”，以及如何激活可能会受到调节的病理生理学的情况。
Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological processes in the human body. In the last decade, considerable interest in galectin-3 has emerged because of its potential role as a biotarget. Galectin-3 is differentially expressed depending on the tissue type, however its expression can be induced under conditions of tissue injury or stress. Galectin-3 overexpression and secretion is associated with several diseases and is extensively studied in the context of fibrosis, heart failure, atherosclerosis and diabetes mellitus. Monomeric (extracellular) galectin-3 usually undergoes further “activation” which significantly broadens the spectrum of biological activity mainly by modifying its carbohydrate-binding properties. Self-interactions of this protein appear to play a crucial role in regulating the extracellular activities of this protein, however there is limited and controversial data on the mechanisms involved. We therefore summarize (recent) literature in this area and describe galectin-3 from a binding perspective providing novel insights into mechanisms by which galectin-3 is known to be “activated” and how such activation may be regulated in pathophysiological scenarios.