Selenium enrichment of broccoli: Interactions between selenium and secondary plant compounds
Selenium enrichment of broccoli: Interactions between selenium and secondary plant compounds
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DOI：
10.1093/jn/135.5.1236
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发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
Hintze, KJ
中科院分区：
文献类型：
--
作者：
Finley, JW;Sigrid-Keck, A;Hintze, KJ
西兰花的多种成分，例如萝卜硫素 (Sf) 和酚酸，可以抑制癌症。此外，西兰花可以积累硒 (Se)，硒已被证明可以降低患癌症的风险。进行了研究以确定用硒增强西兰花是否会产生具有优越健康益处的植物。尽管增加西兰花中硒的浓度<< 1.0 至> 800μg/g对大鼠结肠癌有抑制作用，并降低了Sf含量>GT; 80% 并抑制大多数酚酸的产生。在大鼠饮食中添加富硒西兰花诱导的硒蛋白硫氧还蛋白还原酶活性超过了单独硒诱导的最大活性。这些结果强调了食品中生物活性化学物质的复杂相互作用；尝试最大化一种成分可能会影响另一种成分的积累，并且消耗大量多种生物活性化合物可能会导致体内意想不到的代谢相互作用。
Multiple components of broccoli, such as sulforaphane (Sf) and phenolic acids, may inhibit cancer. Additionally, broccoli can accumulate selenium (Se), and Se has been demonstrated to reduce the risk of cancer. Studies were conducted to determine whether enhancement of broccoli with Se would produce a plant with superior health benefits. Although increasing the concentration of Se in broccoli from < 1.0 to > 800 μ g/g resulted in inhibition of colon cancer in rats, it also decreased the Sf content by > 80% and inhibited production of most phenolic acids. The inclusion of Se-enriched broccoli in the diet of rats induced the activity of the selenoprotein thioredoxin reductase beyond the maximum activity induced by Se alone. These results emphasize the complex interactions of bioactive chemicals in a food; attempts to maximize one component may affect accumulation of another, and consumption of high amounts of multiple bioactive compounds may result in unexpected metabolic interactions within the body.