BODY-COMPOSITION IN ADULT GROWTH HORMONE-DEFICIENT MEN, ASSESSED BY ANTHROPOMETRY AND BIOIMPEDANCE ANALYSIS
BODY-COMPOSITION IN ADULT GROWTH HORMONE-DEFICIENT MEN, ASSESSED BY ANTHROPOMETRY AND BIOIMPEDANCE ANALYSIS
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DOI：
10.1210/jc.75.3.833
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发表时间：
1992-09-01
影响因子：
5.8
通讯作者：
VANDERVEEN, EA
中科院分区：
文献类型：
--
作者：
DEBOER, H;BLOK, GJ;VANDERVEEN, EA
采用人体测量和生物阻抗分析（BIA）评估42名GHD缺乏（GHD）成年男性（平均年龄27.2±4.7岁）的身体成分。在儿童时期，所有患者接受生长激素治疗的平均时间为8.4 +/- 3.8年。在研究开始时，生长激素治疗的平均时间为7.5 +/- 4.5年。18名患者患有孤立性生长激素缺乏症（1-GHD）。24例有多发性垂体激素缺乏（M-PHD），经适当替代。与年龄和性别匹配的对照组相比，I-GHD和M-PHD患者在7个不同部位测量的皮肤褶皱总数明显更高[对照组，73.1 +/- 25.4 mm；I-GHD患者，102.1 +/- 37.7 mm (P < 0.001)；M-PHD患者，126.8 +/- 35.4 mm （P < 0.001）。sc脂肪沉积的增加在躯干最明显，尤其是在乳房和腹部。GHD患者的全身肌肉质量显著降低（P < 0.001）。患者体肌质量与血浆生长激素- c水平呈正相关（r = 0.43; P < 0.005）。患者组全身BIA测定的全身阻力显著高于对照组，且与血浆生长激素- c呈负相关（r = -0.53; P < 0.001）。在GHD患者中观察到的高阻值只能部分解释为他们较低的瘦体重。然而，最重要的原因是瘦体质量（LBM）的比电阻增加，反映了相对脱水。我们得出结论，成年男性的生长激素缺乏与sc脂肪的增加和身体肌肉质量的减少有关。此外，LBM也发生了质的变化。BIA数据表明，在这些患者中，由于细胞外水的减少，LBM的水合状态低于正常水平。
Anthropometry and bioimpedance analysis (BIA) were used to assess body composition in 42 GH-deficient (GHD) adult males (mean age, 27.2 +/- 4.7 yr). During childhood, all patients had received GH treatment for a mean period of 8.4 +/- 3.8 yr. At the start of this study, GH therapy had been discontinued for a mean period of 7.5 +/- 4.5 yr. Eighteen patients had isolated GH deficiency (1-GHD). Twenty-four patients had multiple pituitary hormone deficiencies (M-PHD), substituted adequately. Compared to age- and sex-matched controls, the sum of skinfolds measured at 7 different sites was significantly higher in I-GHD and M-PHD patients [controls, 73.1 +/- 25.4 mm; I-GHD patients, 102.1 +/- 37.7 mm (P < 0.001); M-PHD patients, 126.8 +/- 35.4 mm (P < 0.001)]. The increase in sc fat deposition was most pronounced on the trunk, particularly in the breast and abdominal area. Total body muscle mass was significantly lower in GHD patients (P < 0.001). In patients, body muscle mass and plasma somatomedin-C level were positively correlated (r = 0.43; P < 0.005).Total body resistance measured by whole body BIA was significantly higher in the patient group and was negatively correlated with plasma somatomedin-C (r = -0.53; P < 0.001). The high resistance values observed in GHD patients could only in part be explained by their lower lean body mass. The most important cause, however, was an increase in specific electrical resistance of the lean body mass (LBM), reflecting relative dehydration.We conclude that GH deficiency in adult males is associated with an increase in sc fat and a decrease in body muscle mass. In addition, there is a qualitative change in LBM. The BIA data indicate that in these patients, the hydration state of the LBM is lower than normal, due to a decrease in extracellular water.