The fine structure of acquired immunodeficiency syndrome encephalopathy.
The fine structure of acquired immunodeficiency syndrome encephalopathy.
复制标题
获得性免疫缺陷综合征脑病的精细结构。
DOI：
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发表时间：
1989
影响因子：
4.6
通讯作者：
C. del Rio
中科院分区：
文献类型：
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作者：
S. Mirra;C. del Rio
人类免疫缺陷病毒累及中枢神经系统被认为是获得性免疫缺陷综合征（AIDS）脑病的临床和病理特征的基础。尽管形态学、免疫细胞化学和分子数据表明多核和单核巨噬细胞、神经胶质细胞和其他细胞的人类免疫缺陷病毒感染占主导地位，但也被认为参与其中。活检组织的电子显微镜研究，可能进一步确定神经病理学变化已受到限制。研究一名38岁男性急性痴呆和艾滋病脑病患者的保存完好的活检组织的机会促使了这份报告。人类免疫缺陷病毒从多核和单核细胞表面出芽，具有巨噬细胞的形态特征;罕见的星形胶质细胞过程也显示出病毒感染的证据。在血管壁内观察到巨噬细胞，并与神经细胞内的淋巴细胞密切接触。值得注意的是罕见的是管网状包涵体，干扰素相关的细胞质结构，常见于系统的内皮细胞和淋巴细胞在艾滋病。它们的相对缺乏可能意味着艾滋病脑病中干扰素的产生减少。
Involvement of the central nervous system with the human immunodeficiency virus is thought to underlie the clinical and pathologic features of acquired immunodeficiency syndrome (AIDS) encephalopathy. Although morphologic, immunocytochemical, and molecular data point to predominant human immunodeficiency virus infection of multinucleated and mononuclear macrophages, neuroglial and other cells are thought to be involved as well. Electron microscopic studies of biopsy tissue that might further define the neuropathologic changes have been limited. The opportunity to study well-preserved biopsy tissue from a 38-year-old man with the acute onset of dementia and AIDS encephalopathy prompted this report. Human immunodeficiency virus was seen budding from the surface of multinucleated and mononuclear cells with morphologic features of macrophages; a rare astrocyte process showed evidence of viral infection as well. Macrophages were noted within the walls of blood vessels and in intimate contact with lymphocytes within the neuropil. Notably rare were tubuloreticular inclusions, interferon-related cytoplasmic structures commonly found in systemic endothelial cells and lymphocytes in AIDS. Their relative scarcity may signify reduced interferon production in AIDS encephalopathy.