TREATMENT OF ADVANCED REFRACTORY OVARIAN-CARCINOMA WITH A GONADOTROPIN-RELEASING HORMONE ANALOG
TREATMENT OF ADVANCED REFRACTORY OVARIAN-CARCINOMA WITH A GONADOTROPIN-RELEASING HORMONE ANALOG
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DOI：
10.1016/0002-9378(89)90669-8
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发表时间：
1989-11-01
影响因子：
9.8
通讯作者：
MOTWANI, BT
中科院分区：
文献类型：
--
作者：
BRUCKNER, HW;MOTWANI, BT
醋酸Leuprolide是一种促性腺激素释放激素类似物，在5例卵巢癌患者中产生了各种有益的治疗反应。4例患者使用烷基化剂、顺铂和阿霉素强化化疗失败。所有患者都有一种或多种临床症状，无法使用细胞毒性药物治疗，并且具有与激素治疗耐药相关的特征。我们的研究结果支持对难治性卵巢癌的新激素治疗扩大资格标准的评价。
Leuprolide acetate, a gonadotropin-releasing hormone analogue, produced a variety of beneficial therapeutic responses in five patients with ovarian carcinoma. Four patients had failed intensive chemotherapy with alkylating agents, cisplatin, and Adriamycin. All had one or more clinical conditions that precluded treatment with cytotoxic agents and characteristics associated with resistance to hormone therapy. Our findings support evaluation of expanded eligibility criteria for new hormonal therapy in cases of refractory ovarian carcinoma.