Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
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DOI：
10.1161/01.hyp.33.5.1111
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发表时间：
1999-05-01
期刊：
影响因子：
8.3
通讯作者：
Safar, ME
中科院分区：
文献类型：
--
作者：
Blacher, J;Asmar, R;Safar, ME
大动脉损伤是高血压患者心血管疾病发病和死亡的主要因素。脉搏波速度（Pulse wave velocity， PWV）是动脉扩张性的经典评价指标，但从未被确定为心血管危险指标。为了确定影响主动脉PWV的因素及其潜在的预测作用，我们研究了710例原发性高血压患者。动脉粥样硬化改变（AA）是根据临床事件定义的。使用Framingham方程计算无AA受试者的心血管风险。AA存在时PWV更高（14.9+/-4.0 vs 12.4+/-2.6 m/s）， P13 m/s单独作为心血管死亡率的一个强有力的预测指标，具有很高的性能值。这项研究表明，主动脉PWV与动脉粥样硬化的存在和程度密切相关，是高血压患者心血管风险的有力标志和预测因素。
Large artery damage is a major contributory factor to cardiovascular morbidity and mortality of patients with hypertension. Pulse wave velocity (PWV), a classic evaluation of arterial distensibility, has never been ascertained as a cardiovascular risk marker. To determine the factors influencing aortic PWV and the potential predictor role of this measurement, we studied a cohort of 710 patients with essential hypertension. Atherosclerosis alterations (AA) were defined on the basis of clinical events. Calculation of cardiovascular risks, by use of Framingham equations, was performed in subjects without AA. PWV was higher in the presence of AA (14.9+/-4.0 versus 12.4+/-2.6 m/s, P13 m/s, taken alone, appeared as a strong predictor of cardiovascular mortality with high performance values. This study shows that aortic PWV is strongly associated with the presence and extent of atherosclerosis and constitutes a forceful marker and predictor of cardiovascular risk in hypertensive patients.