SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
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DOI：
10.1002/gcc.10222
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发表时间：
2003-07-01
影响因子：
3.7
通讯作者：
Tien, HF
中科院分区：
文献类型：
--
作者：
Chen, CY;Tsay, W;Tien, HF
造血前体细胞的增殖和分化依赖于多种细胞因子。细胞因子信号转导抑制因子-1（SOCS 1）下调Janus激酶/信号转导和转录激活因子（jAK/STAT）通路活性并抑制细胞因子的生物学效应。SOCS I已被证明具有肿瘤抑制活性，该基因的甲基化导致转录沉默，已在65%的肝细胞癌中发现，并被认为在癌症的发展中起重要作用。SOCS 1基因在急性髓系白血病（AML）中的甲基化状态未见报道。在这项研究中，我们分析了89例新诊断的AML患者的SOCS 1甲基化，并将结果与免疫表型，细胞遗传学，临床特征和治疗结果相关联。SOCS 1甲基化在53例患者（60%）的白血病细胞中发现。17例t（15;17）患者中有13例（76%）发生SOCS 1甲基化，而9例t（8;21）患者中只有1例（11%）发生SOCS 1甲基化。SOCS 1基因甲基化频率在不同细胞遗传学亚群间差异有统计学意义（P = 0.014）。其他临床和实验室参数以及无病生存期和总生存期在有和无SOCS 1甲基化的患者之间相似。总之，SOCS 1甲基化发生在超过一半的AML病例中，与细胞遗传学异常相关，并可能在AML亚群的发展中发挥重要作用。(C)2003 Wiley-Liss，Inc.
The proliferation and differentiation of hematopoietic precursor cells depend on various cytokines. The suppressor of cytokine signaling-1 (SOCS1) down-regulates Janus kinases/signal transducers and activators of transcription (jAK/STAT) pathway activity and inhibits the biological effects of cytokines. SOCS I has been shown to have tumor-suppressor activity, and methylation of this gene, resulting in transcriptional silencing, has been found in 65% of hepatocellular carcinoma and has been suggested to play an important role in the development of the cancer. The methylation status of the SOCS1 gene in acute myeloid leukemia (AML) has not been reported before. In this study, we analyzed SOCS1 methylation in 89 patients with newly diagnosed AML and correlated the result with immunophenotypes, cytogenetics, clinical features, and treatment outcome. SOCS1 methylation was found in the leukemic cells from 53 patients (60%). Thirteen (76%) of the 17 patients with t(15;17) had SOCS1 methylation, whereas this gene was methylated in only one (11%) of the nine patients with t(8;21). The frequencies of SOCS1 methylation among various cytogenetic subgroups differed significantly (P = 0.014). Other clinical and laboratory parameters and the disease-free survival and overall survival were similar between patients with and without SOCS1 methylation. In conclusion, SOCS1 methylation occurs in more than half of AML cases, correlates with cytogenetic abnormalities, and may play an important role in the development of subsets of AML. (C) 2003 Wiley-Liss, Inc.