Vesicular glutamate release from axons in white matter
Vesicular glutamate release from axons in white matter
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DOI：
10.1038/nn1850
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发表时间：
2007-03-01
影响因子：
25
通讯作者：
Dietrich, Dirk
中科院分区：
文献类型：
--
作者：
Kukley, Maria;Capetillo-Zarate, Estibaliz;Dietrich, Dirk
神经递质的囊泡释放是脑内神经元的普遍输出信号。一般认为，快速递质释放仅限于与灰质中的突触后细胞接触的神经末梢。在这里，我们表明，在大鼠大脑中，神经递质谷氨酸也释放在离散的网站沿着轴突在白色的问题，在没有神经元和神经末梢。单个动作电位沿着轴突的传播导致谷氨酸的快速囊泡释放，其通过局部少突胶质细胞前体细胞上的离子型谷氨酸受体检测。谷氨酸的轴突释放是可靠的，涉及高度局部化的钙微区信号传导，并且是强烈的钙合作，类似于突触处的囊泡融合。这种轴突递质的释放代表了白色物质中轴突-神经胶质界面高保真、活动依赖性信号传导的一种普遍机制。
Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at discrete sites along axons in white matter in the absence of neurons and nerve terminals. The propagation of single action potentials along axons leads to rapid vesicular release of glutamate, which is detected by ionotropic glutamate receptors on local oligodendrocyte precursor cells. Axonal release of glutamate is reliable, involves highly localized calcium microdomain signaling and is strongly calcium cooperative, similar to vesicle fusion at synapses. This axonal transmitter release represents a widespread mechanism for high-fidelity, activity-dependent signaling at the axon-glia interface in white matter.