IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis
IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis
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DOI：
10.1007/s10875-008-9235-y
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发表时间：
2008-11-01
影响因子：
9.1
通讯作者：
Bayer, Allison L.
中科院分区：
文献类型：
--
作者：
Malek, Thomas R.;Yu, Aixin;Bayer, Allison L.
简介 白细胞介素 2 (IL-2) 诱导 T 调节 (Treg) 细胞的重要信号。如果没有功能性 IL-2R，则只有未成熟的 CD4(+) Foxp3(low) CD25(neg) T 细胞发育，并且这些细胞无法抑制外周的自身反应性 T 细胞。讨论 IL-2 在 Treg 细胞发育过程中通过上调 Foxp3 和 CD25 以及增加胸腺 Treg 细胞的数量发挥作用。在新生儿期离开胸腺后，IL-2 负责快速扩增外周淋巴结中的 Treg 细胞数量，以确保抑制逃避阴性选择的自身反应性 T 细胞，从而维持耐受性。成熟免疫活性小鼠中 Treg 细胞的稳态也依赖于 IL-2。然而，Treg 细胞稳态存在另一种机制，可能代表次要的 IL-2 独立途径或微弱且非常短暂的 IL-2R 信号传导的结果。 结论 因此，IL-2 为 Treg 细胞发育及其在外周免疫组织中的稳态提供了重要信号。
Introduction Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4(+) Foxp3(low) CD25(neg) T cells develop, and these cells fail to suppress autoreactive T cells in the periphery.Discussion IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the thymus during neonatal life, IL-2 is responsible for rapid amplification of the number of Treg cells in peripheral lymph nodes to insure suppression of autoreactive T cells that escape negative selection, thereby maintaining tolerance. The homeostasis of Treg cells in mature immunocompetent mice also depends on IL-2. However, there is an alternative mechanism for Treg cells homeostasis that may represent a minor IL-2-independent pathway or the consequence of weak and very transient IL-2R signaling.Conclusion Thus, IL-2 provides importance signals for Treg cell development and for their homeostasis in peripheral immune tissues.