New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension.
New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension.
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DOI：
10.3389/fphys.2020.01081
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发表时间：
2020
影响因子：
4
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Hu L;Zhao R;Liu Q;Li Q
肺动脉高压（PAH）是一种多因素的进行性疾病。这种疾病的特征是血管收缩和血管重塑，这导致肺动脉压和肺血管阻力增加。虽然已经进行了广泛的研究，以了解病因，它仍然不清楚是什么细胞内因素的贡献和整合这些病理特征。热休克蛋白90（Heat shock protein 90，Hsp90）是一种广泛存在的必需分子伴侣，参与多种蛋白质的成熟。越来越多的研究表明，Hsp90的异常表达与PAH相关的细胞因子如可溶性鸟苷酸环化酶和AMP激活的蛋白激酶之间存在直接联系。这些研究表明，Hsp90调控网络是不良结局的主要预测因子，为PAH的发病机制提供了新的见解。首次，这篇综述总结了热休克蛋白90失调和不同的蛋白质参与PAH的发展之间的相互作用，脱落的内在发病机制和潜在的新的治疗策略，这种毁灭性的疾病的新的见解。
Pulmonary arterial hypertension (PAH) is a multifactorial and progressive disorder. This disease is characterized by vasoconstriction and vascular remodeling, which results in increased pulmonary artery pressure and pulmonary vascular resistance. Although extensive studies have been carried out to understand the etiology, it is still unclear what intracellular factors contribute and integrate these pathological features. Heat shock protein 90 (Hsp90), a ubiquitous and essential molecular chaperone, is involved in the maturation of many proteins. An increasing number of studies have revealed direct connections between abnormal Hsp90 expression and cellular factors related to PAH, such as soluble guanylate cyclase and AMP-activated protein kinase. These studies suggest that the Hsp90 regulatory network is a major predictor of poor outcomes, providing novel insights into the pathogenesis of PAH. For the first time, this review summarizes the interplay between the Hsp90 dysregulation and different proteins involved in PAH development, shedding novel insights into the intrinsic pathogenesis and potentially novel therapeutic strategies for this devastating disease.
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