Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268:: Characterization of 2-deoxy-scyllo-inosose synthase
Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268:: Characterization of 2-deoxy-scyllo-inosose synthase
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DOI：
10.1038/ja.2006.51
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Eguchi, Tadashi
中科院分区：
文献类型：
--
作者：
Hirayama, Toshifumi;Tamegai, Hideyuki;Eguchi, Tadashi
从印度斯坦链霉菌（Streptoalloteichus hindustanus）中鉴定出含2 -脱氧链霉碱抗生素的新生物合成基因簇的一部分。该基因簇中的alloH基因被推测为编码2-脱氧鲨肌醇合酶，表达的蛋白质AlloH被证实具有该酶的活性。并对AlloH的生化特性进行了研究。
A part of the new biosynthetic gene cluster for 2 -deoxystreptarnine-containing antibiotics was identified from Streptoalloteichus hindustanus. The alloH gene in the gene cluster was deduced to encode 2-deoxy-scyllo-inosose synthase and the expressed protein AlloH was confirmed to have this enzyme activity. Furthermore, biochemical properties of AlloH were studied.