Systemic AA amyloidosis as a prion-like disorder
Systemic AA amyloidosis as a prion-like disorder
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DOI：
10.1016/j.virusres.2014.12.019
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发表时间：
2015-09-02
期刊：
影响因子：
5
通讯作者：
Ishiguro, Naotaka
中科院分区：
文献类型：
--
作者：
Murakami, Tomoaki;Inoshima, Yasuo;Ishiguro, Naotaka
淀粉样变性是一组引起器官功能损害的疾病的统称，通过淀粉样蛋白或β折叠中错误折叠的蛋白质的积累而发生。AA淀粉样变性是以SAA为前体蛋白的致死性系统性淀粉样变性，并且在包括人类在内的各种动物物种中观察到。AA淀粉样变性可以通过在实验动物模型中连续给予炎症刺激来人工诱导。在该实验诱导过程中，已知给予来自相同或不同物种的AA淀粉样蛋白显著加速AA淀粉样变性的发展，并且这也被称为AA淀粉样变性的传播。与朊病毒病类似，AA淀粉样变性被认为是通过"种子成核"过程传播的。在这篇文章中，我们回顾了动物AA淀粉样变性的病理学和遗传性。(C)2014爱思唯尔有限公司版权所有。
Amyloidosis is a collective term for a group of disorders that induce functional impairment of organs and occurs through the accumulation of amyloid, or misfolded protein in beta-sheets. AA amyloidosis is a lethal systemic amyloidosis with SAA as the precursor protein, and is observed in various animal species, including humans. AA amyloidosis can be induced artificially by continuously administering inflammatory stimuli in experimental animal models. In this process of experimental induction, the administration of AA amyloids from either the same or different species is known to markedly expedite AA amyloidosis development, and this is also termed transmission of AA amyloidosis. Similarly to prion disease, AA amyloidosis is considered to be transmitted via a "seeding-nucleation" process. In this manuscript, we reviewed the pathology and transmissibility of AA amyloidosis in animals. (C) 2014 Elsevier B.V. All rights reserved.