Antibacterial Adhesion of Borneol-Based Polymer via Surface Chiral Stereochemistry
Antibacterial Adhesion of Borneol-Based Polymer via Surface Chiral Stereochemistry
复制标题
通过表面手性立体化学实现冰片基聚合物的抗菌粘附
DOI：
10.1021/am505481q
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发表时间：
2014-11-12
影响因子：
9.5
通讯作者：
Wang, Xing
中科院分区：
文献类型：
--
作者：
Luo, Lingqiong;Li, Guofeng;Wang, Xing
细胞在外表面的黏附过程中，表现出明显的不同分子手性倾向，这促使我们开发一种新型的抗菌材料，以迎合细菌的手性味道。以天然产物冰片(一种樟脑型双环单萜)为基础，成功地合成了一系列冰片基聚合物--聚冰片丙烯酸酯(PBA)，由于冰片异构体在材料表面具有优异的抗菌黏附性能。本研究的结果表明，细菌只是不喜欢这种类型的PBA顽固的表面，PBA表面的立体化学有助于界面的抗菌活性。PBA聚合物被评价为无细胞毒性，并且可以简单地合成，显示了它们在生物医学应用中的巨大潜力。
During its adhesion on external surfaces, a cell exhibits obvious inclination to different molecular chirality, which encourages us to develop a new type of antibacterial material catering to the "chiral taste" of bacteria. On the basis of the natural product borneol (a camphane-type bicyclic monoterpene), a series of borneol-based polymer, polyborneolacrylate (PBA), was successfully prepared and showed superior antibacterial adhesion properties resulting from the borneol isomers on material surface. The results of this study reveal that bacteria simply dislike this type of stubborn surface of PBA, and the PBA surface stereochemistry contributes to the interfacial antibacterial activities. The PBA polymers were evaluated as noncytotoxic and can be simply synthesized, demonstrating their great potential for biomedical applications.