Model-based experimental design for assessing effects of mixtures of chemicals
Model-based experimental design for assessing effects of mixtures of chemicals
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DOI：
10.1016/j.envpol.2009.07.030
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发表时间：
2010-01-01
影响因子：
8.9
通讯作者：
Kooijman, Sebastiaan A. L. M.
中科院分区：
文献类型：
--
作者：
Baas, Jan;Stefanowicz, Anna M.;Kooijman, Sebastiaan A. L. M.
我们暴露面粉甲虫（赤拟谷盗）的混合物的四个多环芳烃（PAHs）。选择实验装置，以便重点是评估部分效应。我们通过基于过程的模型解释了混合物的影响，并确定了对生存影响的阈值浓度。阈值浓度的行为是本研究的关键特征之一。我们表明，阈值浓度是共享的毒物具有相同的作用模式，这给出了一个机械解释的观察，在混合物中的毒性效应可能会发生在浓度范围内的个别组件不显示效果。我们的方法提供了可靠的预测部分影响生存，并允许减少实验工作，在评估混合物的影响，外推到其他混合物，其他时间点，或在更广泛的角度来看，其他生物体。(C)2009爱思唯尔有限公司保留所有权利。
We exposed flour beetles (Tribolium castaneum) to a mixture of four poly aromatic hydrocarbons (PAHs). The experimental setup was chosen such that the emphasis was on assessing partial effects. We interpreted the effects of the mixture by a process-based model, with a threshold concentration for effects on survival. The behavior of the threshold concentration was one of the key features of this research. We showed that the threshold concentration is shared by toxicants with the same mode of action, which gives a mechanistic explanation for the observation that toxic effects in mixtures may occur in concentration ranges where the individual components do not show effects. Our approach gives reliable predictions of partial effects on survival and allows for a reduction of experimental effort in assessing effects of mixtures, extrapolations to other mixtures, other points in time, or in a wider perspective to other organisms. (C) 2009 Elsevier Ltd. All rights reserved.