NEUROANATOMICAL DIFFERENCES BETWEEN DYSLEXIC AND NORMAL READERS ON MAGNETIC-RESONANCE-IMAGING SCANS
NEUROANATOMICAL DIFFERENCES BETWEEN DYSLEXIC AND NORMAL READERS ON MAGNETIC-RESONANCE-IMAGING SCANS
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DOI：
10.1001/archneur.1991.00530160078018
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发表时间：
1991-04-01
影响因子：
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通讯作者：
LUBS, H
中科院分区：
文献类型：
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作者：
DUARA, R;KUSHCH, A;LUBS, H
在从21名诵读困难者和29名对照受试者获得的磁共振图像上测量了水平脑切片上左右半球六个双侧脑段的面积以及中矢状脑切片上胼胝体分区的面积。在整个组中，水平脑切片的前半部分显示不对称，右侧较大，而后部仅枕极段不对称，左侧较大。阅读障碍的受试者表现出不对称性，右侧大于左侧，与通常在中后段（对应于角回）观察到的相对对称的模式相反。在胼胝体，被发现有障碍的受试者有一个较大的压部比nondyslearies受试者，和有障碍的女性受试者被发现有一个较大的压部比有障碍的男性受试者。由于连接左右角回区域的经胼胝体通路穿过胼胝体压部，因此在阅读障碍受试者中的上述发现表明角回区域的解剖异常。
The areas of six bilateral brain segments in the right and left hemispheres, on a horizontal brain section, and the area of subdivisions of the corpus callosum, on a midsagittal brain section, were measured on magnetic resonance images obtained from 21 dyslexic and 29 control subjects. In the entire group, the frontal half of the horizontal brain section showed asymmetry, with the right side being larger, whereas posteriorly only the occipital polar segment was asymmetrical, with the left side being larger. Dyslexic subjects exhibited asymmetry, with the right side greater than the left side, in contrast to the relatively symmetrical pattern that is normally observed in the midposterior segment that corresponds to the angular gyrus. In the corpus callosum, dyslexic subjects were found to have a larger splenium than nondyslexic subjects, and dyslexic female subjects were found to have a larger splenium than dyslexic male subjects. Because transcallosal pathways connecting the left and right angular gyrus regions traverse through the splenium of the corpus callosum, the above findings in dyslexic subjects suggest an anatomic abnormality in the angular gyrus region.