Human Papovavirus (JC): Induction of Brain Tumors in Hamsters
Human Papovavirus (JC): Induction of Brain Tumors in Hamsters
复制标题
人类乳头多空病毒 (JC)：诱导仓鼠脑肿瘤
作者：
D. Walker;B. Padgett;G. ZuRhein;A. E. Albert;R. Marsh
83%的仓鼠在出生时接种JC病毒，这是一种从进行性多灶性白质脑病病例的脑组织中分离出的人类乳多空病毒，在6个月内发展为恶性胶质瘤。三个脑肿瘤已连续移植为皮下肿瘤。JC病毒分离自测试的七个肿瘤中的五个。体外培养四种肿瘤细胞。这些细胞含有具有T抗原特征的核内抗原，并且该抗原与SV 40 T抗原抗原相关。虽然病毒不能从连续培养的肿瘤细胞提取物中回收，但当一种肿瘤细胞系与允许细胞融合时，JC病毒被拯救。
Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.