The prevention of prosthetic infection using a cross-linked albumin coating in a rabbit model
The prevention of prosthetic infection using a cross-linked albumin coating in a rabbit model
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DOI：
10.1302/0301-620x.79b5.7228
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发表时间：
1997-09-01
影响因子：
--
通讯作者：
Friedman, RJ
中科院分区：
文献类型：
--
作者：
An, YH;Bradley, J;Friedman, RJ
我们评估了 29 只成年雄性兔子的血清蛋白涂层对假体感染的影响，这些兔子分为三组：对照组、白蛋白涂层和未涂层。我们使用了 34 个经过喷砂处理的商业纯钛植入物。十一个被交联白蛋白包被。所有植入物在植入前均暴露于表皮葡萄球菌悬浮液中。我们的研究结果表明，白蛋白涂层植入物的感染率（27%）比未涂层植入物（62%）低得多。这可能是减少假体感染的有效方法。
We evaluated the effects of a serum protein coating on prosthetic infection in 29 adult male rabbits divided into three groups: control, albumin-coated and uncoated. We used 34 grit-blasted, commercially pure titanium implants. Eleven were coated with cross-linked albumin. All the implants were exposed to a suspension of Staphylococcus epidermidis before implantation.Our findings showed that albumin-coated implants had a much lower infection rate (27%) than the uncoated implants (62%). This may be a useful method of reducing the infection of prostheses.